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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Nov 27, 2025; 17(11): 110306
Published online Nov 27, 2025. doi: 10.4240/wjgs.v17.i11.110306
Published online Nov 27, 2025. doi: 10.4240/wjgs.v17.i11.110306
Preoperative malignancy risk assessment in pancreatic cystic neoplasms using clinical and laboratory parameters
Hüseyin Fahri Martli, Department of General Surgery, Ankara City Hospital, Ankara 06100, Türkiye
Fatih Acehan, Department of Internal Medicine, Ankara City Hospital, Ankara 06800, Türkiye
Ahmet Şimşek, Aziz Ahmet Sürel, Department of Surgery, Ankara Bilkent City Hospital, Ankara 06800, Türkiye
Eda Şahingöz, Department of General Surgery, University of Health Sciences, Ankara 06100, Türkiye
Sadettin Er, Department of General Surgery, Ankara Bilkent City Hospital, Ankara 06800, Türkiye
Mesut Tez, Department of Surgery, University of Health Sciences, Ankara City Hospital, Ankara 06800, Türkiye
Author contributions: Martli HF contributed to data curation, investigation, methodology, project administration, supervision, writing-review and editing; Martli HF, Şimşek A, Şahingöz E, Sürel AA, Er S, and Tez M contributed to conceptualization, resources, and writing-original draft; Acehan F contributed to statistical analyses; Şimşek A, Şahingöz E, Sürel AA, Er S, and Tez M contributed to supporting of software and visualization. All authors read and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of Ankara Bilkent City Hospital (Approval No. E-1-23-3616).
Informed consent statement: Informed consent was not obtained due to the retrospective nature of the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The datasets analyzed during the current study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mesut Tez, Department of Surgery, University of Health Sciences, Ankara City Hospital, No. 1 Bilkent Street, District of Universities, Ankara 06800, Türkiye.
Received: June 4, 2025
Revised: June 18, 2025
Accepted: September 16, 2025
Published online: November 27, 2025
Processing time: 174 Days and 15 Hours
Revised: June 18, 2025
Accepted: September 16, 2025
Published online: November 27, 2025
Processing time: 174 Days and 15 Hours
Core Tip
Core Tip: This study highlights the utility of simple preoperative parameters - age and red cell distribution width - in predicting malignancy in pancreatic cystic neoplasms. With area under the curve values of 0.798 and 0.801, respectively, and a combined area under the curve of 0.858, these markers can guide patient selection for endoscopic ultrasonography and cytological evaluation, potentially improving surgical decision-making for pancreatic cystic neoplasms.