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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Oct 27, 2025; 17(10): 109404
Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.109404
Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.109404
Study on the neuroimmune regulatory mechanism of electroacupuncture at Zusanli acupoint for postoperative intestinal paralysis after gastrointestinal surgery
Jing-Yan Xu, Cheng Li, Department of Acupuncture and Moxibustion, Jiangnan University Affiliated Hospital, Wuxi 214000, Jiangsu Province, China
Author contributions: Xu JY designed the study, Xu JY and Li C analyzed the data, and Xu JY and Li C were involved in the data collection and writing of this article; all authors have read and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of Jiangnan University Affiliated Hospital.
Informed consent statement: All study participants and their legal guardians provided written informed consent before enrollment.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Cheng Li, Deputy Director, Department of Acupuncture and Moxi
Received: June 17, 2025
Revised: July 25, 2025
Accepted: August 26, 2025
Published online: October 27, 2025
Processing time: 128 Days and 16.2 Hours
Revised: July 25, 2025
Accepted: August 26, 2025
Published online: October 27, 2025
Processing time: 128 Days and 16.2 Hours
Core Tip
Core Tip: This study revealed that electroacupuncture at the Zusanli acupoint can enhance the clinical efficacy of postoperative intestinal paralysis after gastrointestinal surgery, promote the recovery of gastrointestinal function, and regulate the neuroimmune microenvironment. This mechanism may involve vagus nerve excitation and activation of the cholinergic anti-inflammatory pathway.