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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Oct 27, 2025; 17(10): 108479
Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.108479
Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.108479
Association of serum hepatitis B surface antigen with hepatitis B virus DNA and hepatic function in patients with chronic hepatitis B
Jie Li, Meng Li, Hui Sun, Yan-Ting Yu, Yu-Hang Zhou, Lei Yan, Preventive Health Care and Chronic Disease Management Center, Kunming Third People's Hospital, Yunnan Provincial Infectious Disease Clinical Medicine Center, Kunming 650200, Yunnan Province, China
Fei Fu, Department of Internal Medicine, Kunming Third People's Hospital, Yunnan Provincial Infectious Disease Clinical Medicine Center, Kunming 650200, Yunnan Province, China
Co-first authors: Jie Li and Meng Li.
Author contributions: Li J and Li M contributed to the conception, design, data analysis, and manuscript drafting and editing; Li J, Li M, Sun H, Yu YT, Zhou YH, Fu F, and Yan L contributed to the data collection and assembly, and manuscript revision; Li J, Li M, and Yan L contributed to the conception, resources, and manuscript review and editing; All authors have read and approved the final manuscript. Li J and Li M contributed equally to this study as co-first authors.
Institutional review board statement: This study was approved by the Ethic Committee of Kunming Third People's Hospital.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lei Yan, Preventive Health Care and Chronic Disease Management Center, Kunming Third People's Hospital, Yunnan Provincial Infectious Disease Clinical Medicine Center, No. 319 Wujing Road, Guandu District, Kunming 650200, Yunnan Province, China. 13320507389@163.com
Received: May 23, 2025
Revised: July 3, 2025
Accepted: August 25, 2025
Published online: October 27, 2025
Processing time: 153 Days and 16.9 Hours
Revised: July 3, 2025
Accepted: August 25, 2025
Published online: October 27, 2025
Processing time: 153 Days and 16.9 Hours
Core Tip
Core Tip: Few studies have comprehensively examined the association between serum hepatitis B surface antigen (HBsAg) levels, hepatitis B virus (HBV) DNA, and liver function in patients with chronic hepatitis B (CHB), particularly regarding its value as a noninvasive predictor of high viral replication and severe liver damage. This study assessed the clinical sig