Chen L, Wang L, Wang H. Comparison of stereotactic body radiotherapy following transcatheter arterial chemoembolization vs transcatheter arterial chemoembolization alone in hepatocellular carcinoma. World J Gastrointest Surg 2025; 17(10): 105360 [DOI: 10.4240/wjgs.v17.i10.105360]
Corresponding Author of This Article
Hui Wang, MM, Medical Imaging Center, Central Hospital Affiliated to Shandong First Medical University (Jinan Central Hospital), No. 105 Jiefang Road, Lixia District, Jinan 250013, Shandong Province, China. wanghui85341@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Oct 27, 2025 (publication date) through Oct 24, 2025
Times Cited of This Article
Times Cited (0)
Journal Information of This Article
Publication Name
World Journal of Gastrointestinal Surgery
ISSN
1948-9366
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Chen L, Wang L, Wang H. Comparison of stereotactic body radiotherapy following transcatheter arterial chemoembolization vs transcatheter arterial chemoembolization alone in hepatocellular carcinoma. World J Gastrointest Surg 2025; 17(10): 105360 [DOI: 10.4240/wjgs.v17.i10.105360]
World J Gastrointest Surg. Oct 27, 2025; 17(10): 105360 Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.105360
Comparison of stereotactic body radiotherapy following transcatheter arterial chemoembolization vs transcatheter arterial chemoembolization alone in hepatocellular carcinoma
Lin Chen, Liang Wang, Hui Wang
Lin Chen, Liang Wang, Department of Radiology, The Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University, Wuhan 430014, Hubei Province, China
Hui Wang, Medical Imaging Center, Central Hospital Affiliated to Shandong First Medical University (Jinan Central Hospital), Jinan 250013, Shandong Province, China
Co-first authors: Lin Chen and Liang Wang.
Author contributions: Chen L and Wang L contributed equally to this work and share first authorship; Chen L was responsible for data collection, statistical analysis, and manuscript drafting; Wang L contributed to study design, patient follow-up, and interpretation of results; Wang H supervised the entire study, including conceptualization, methodology development, critical revision of the manuscript, and final approval of the version to be submitted.
Institutional review board statement: This study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of Jinan Central Hospital, Affiliated to Shandong First Medical University (Approval No. c2024-08-0026).
Informed consent statement: Written informed consent was obtained from all participants prior to enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets generated and/or analyzed during the current study are not publicly available due to patient privacy and institutional regulations but are available from the corresponding author upon reasonable request at wanghui85341@163.com.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hui Wang, MM, Medical Imaging Center, Central Hospital Affiliated to Shandong First Medical University (Jinan Central Hospital), No. 105 Jiefang Road, Lixia District, Jinan 250013, Shandong Province, China. wanghui85341@163.com
Received: February 18, 2025 Revised: April 6, 2025 Accepted: August 8, 2025 Published online: October 27, 2025 Processing time: 247 Days and 17.2 Hours
Core Tip
Core Tip: Combining transcatheter arterial chemoembolization (TACE) and stereotactic body radiation therapy (SBRT) significantly enhanced local tumor control and prolonged progression-free survival in unresectable hepatocellular carcinoma. Despite a mild increase in hepatic toxicity, it remained manageable and reversible, with most patients recovering by three months. The synergy of TACE’s localized chemotherapy and SBRT’s precise high-dose radiation is a promising approach for Barcelona Clinic Liver Cancer stage B, Child-Pugh A patients. Our findings emphasize careful dosing, robust imaging guidance, and close monitoring of liver function to optimize safety. Integration of immunotherapy and further refinements in treatment planning might yield even better outcomes in the future.
