Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Sep 27, 2024; 16(9): 3032-3040
Published online Sep 27, 2024. doi: 10.4240/wjgs.v16.i9.3032
Meningeal cryptococcosis in a pancreas transplant recipient requiring grafectomy: A case report
Ileana Lulic, Gorana Fingler, Dinka Lulic, Jadranka Pavicic Saric, Danko Mikulic, Tajana Filipec Kanizaj, Eleonora Goluza
Ileana Lulic, Gorana Fingler, Jadranka Pavicic Saric, Department of Anaesthesiology, Intensive Care and Pain Medicine, Clinical Hospital Merkur, Zagreb 10000, Croatia
Dinka Lulic, Immediate Medical Care Unit, Saint James Hospital, Sliema SLM-1030, Malta
Danko Mikulic, Department of Surgery, Clinical Hospital Merkur, Zagreb 10000, Croatia
Tajana Filipec Kanizaj, Department of Gastroenterology, Clinical Hospital Merkur, Zagreb 10000, Croatia
Eleonora Goluza, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Center Zagreb, Zagreb 10000, Croatia
Author contributions: Lulic I and Lulic D participated in the research design; Lulic I, Lulic D, Fingler G, Filipec Kanizaj T, Mikulic D, and Pavicic Saric J participated in the performance of the research; Lulic I, Lulic D, Goluza E, and Mikulic D participated in the performance of the data analysis; Lulic I, Lulic D, and Pavicic Saric J participated in the writing of the article; all authors have read and agreed to the published version of the manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this case report.
Conflict-of-interest statement: There are no conflicts of interest to report.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ileana Lulic, MD, Consultant Physician-Scientist, Department of Anaesthesiology, Intensive Care and Pain Medicine, Clinical Hospital Merkur, Zajceva 19, Zagreb 10000, Croatia. ileanalulic@gmail.com
Received: February 26, 2024
Revised: July 17, 2024
Accepted: July 22, 2024
Published online: September 27, 2024
Processing time: 205 Days and 6.5 Hours
Core Tip

Core Tip: The morbidity and mortality arising from invasive cryptococcosis in solid organ transplant recipients are an incentive to establish the lowest possible level of immunosuppression necessary to maintain stable graft function. There is a paucity of data on optimum management strategies and the absence of standard transplantation protocols for the complex subgroup of pancreas organ transplant recipients with invasive cryptococcosis. This short report demonstrates that the intervention of pancreas transplant grafectomy might be an effective surgical treatment option for pancreas transplant recipients with meningeal cryptococcosis, as a path towards securing good outcomes.