Retrospective Cohort Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Sep 27, 2024; 16(9): 2796-2807
Published online Sep 27, 2024. doi: 10.4240/wjgs.v16.i9.2796
Effect of smoking on the risk of gastrointestinal cancer after cholecystectomy: A national population-based cohort study
Minseob Kim, Kyung-Do Han, Seung-Hyun Ko, Yoonkyung Woo, Jae Hyun Han
Minseob Kim, Department of Surgery, Graduate School of Medicine, The Catholic University of Korea, Seoul 06591, South Korea
Kyung-Do Han, Department of Statistics and Actuarial Science, Soongsil University, Seoul 06978, South Korea
Seung-Hyun Ko, Division of Endocrinology and Metabolism, Department of Internal Medicine, St Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon 16247, South Korea
Yoonkyung Woo, Jae Hyun Han, Division of Hepatobiliary-Pancreas Surgery and Liver Transplantation, Department of Surgery, St Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon 16247, South Korea
Co-first authors: Minseob Kim and Kyung-Do Han.
Author contributions: Kim M, Han KD, Ko SH, Woo Y, and Han JH contributed to the conception and design of the study, acquisition of data, drafting of the article, and making critical revisions related to the important intellectual content of the manuscript; All authors approved the final version of the article to be published; Kim M and Han KD are designated as co-first authors in recognition of their equal and substantial contributions to the study; They both played key roles in conception of the study, data acquisition and analysis, and drafting the article.
Supported by the Clinical Research Invigoration Project of the St Vincent’s Hospital, The Catholic University of Korea, No. VC22ZASI0080.
Institutional review board statement: The study was approved by both the Korean National Health Insurance Service and the Institutional Review Board of the Catholic University of Korea (Approval No. VIRB-20220420-001).
Informed consent statement: Because this was a retrospective analysis of medical claims data, the need for informed consent was waived.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The original anonymous dataset is available on request from the corresponding author at gelasius@catholic.ac.kr.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Jae Hyun Han, MD, PhD, Associate Professor, Division of Hepatobiliary-Pancreas Surgery and Liver Transplantation, Department of Surgery, St Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Joongbudae-ro 93, Paldal-gu, Suwon 16247, South Korea. gelasius@catholic.ac.kr
Received: April 1, 2024
Revised: July 4, 2024
Accepted: July 31, 2024
Published online: September 27, 2024
Processing time: 170 Days and 3.1 Hours
Core Tip

Core Tip: The study found that patients who underwent cholecystectomy, especially those who were smokers, had a higher risk of developing colorectal and gastric cancers. The analysis of Korean National Health Insurance data revealed increased risks of gastrointestinal cancer following cholecystectomy, with an association with smoking habits. This emphasizes the need for thorough screening and follow-up in these patients.