Case Control Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Dec 27, 2024; 16(12): 3675-3684
Published online Dec 27, 2024. doi: 10.4240/wjgs.v16.i12.3675
Protective effect of appendectomy against the onset of ulcerative colitis: A case-control study
Min Cui, Chen Shi, Ping Yao
Min Cui, Ping Yao, Department of Gastroenterology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China
Chen Shi, The First Clinical Medical College, Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China
Co-first authors: Min Cui and Chen Shi.
Author contributions: Cui M performed the majority of study and wrote the manuscript; Yao P designed the study and corrected the manuscript; Shi C participated to the collection of the human material and wrote the manuscript.
Supported by National Natural Science Foundation of China, No. 82460110.
Institutional review board statement: The study was approved by the ethics committee review of the First Affiliated Hospital of Xinjiang Medical University (Approval No. K202303-20).
Informed consent statement: All patients gave informed consent.
Conflict-of-interest statement: All the authors have no conflict of interest related to the manuscript.
Data sharing statement: Dataset available from the corresponding author at pingyaozh@xjmu.edu.cn.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ping Yao, MMed, Chief Physician, Professor, Department of Gastroenterology, The First Affiliated Hospital of Xinjiang Medical University, No. 137 Liyushan Road, Urumqi 830000, Xinjiang Uygur Autonomous Region, China. pingyaozh@xjmu.edu.cn
Received: April 11, 2024
Revised: September 18, 2024
Accepted: October 18, 2024
Published online: December 27, 2024
Processing time: 230 Days and 5.3 Hours
Core Tip

Core Tip: Our study found that appendectomy may delay the onset of ulcerative colitis (UC), reduce disease severity, and lessen the scope of involvement. This study provided evidence that appendectomy plays an important role in the occurrence and development of UC. A further prospective randomized trial evaluating the improvement of appendectomy on the disease course of UC may be feasible.