©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Oct 27, 2023; 15(10): 2115-2122
Published online Oct 27, 2023. doi: 10.4240/wjgs.v15.i10.2115
Published online Oct 27, 2023. doi: 10.4240/wjgs.v15.i10.2115
Effects of thrombopoietin pre-treatment on peri-liver transplantation thrombocytopenia in a mouse model of cirrhosis with hypersplenism
Zi-Rong Liu, Ya-Min Zhang, Zi-Lin Cui, Wen Tong, Department of Hepatobiliary Surgery, Tianjin First Central Hospital, Tianjin 300070, China
Author contributions: Liu ZR, Cui ZL, and Tong W designed the research study; Liu ZR and Cui ZL performed the research; Liu ZR and Tong W contributed new reagents and analytic tools; Liu ZR and Cui ZL analyzed the data and wrote the manuscript; Zhang YM is responsible for reviewing the entire study; and all authors have read and approve the final manuscript.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Tianjin Tiancheng New Drug Evaluation Co., Ltd (Approval No. 2023041701).
Conflict-of-interest statement: All authors declare that there are no conflicts of interest.
Data sharing statement: The data of this study can be shared.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Corresponding author: Ya-Min Zhang, MD, Doctor, Department of Hepatobiliary Surgery, Tianjin First Central Hospital, Fukang Road, Nankai District, Tianjin 300070, China.
Received: July 6, 2023
Peer-review started: July 6, 2023
First decision: July 27, 2023
Revised: August 5, 2023
Accepted: August 25, 2023
Article in press: August 25, 2023
Published online: October 27, 2023
Processing time: 113 Days and 1 Hours
Peer-review started: July 6, 2023
First decision: July 27, 2023
Revised: August 5, 2023
Accepted: August 25, 2023
Article in press: August 25, 2023
Published online: October 27, 2023
Processing time: 113 Days and 1 Hours
Core Tip
Core Tip: Our research results confirm that thrombopoietin (TPO) can improve liver function after liver transplantation in mice by enhancing the effect of platelets. Pre-treatment with TPO not only exhibited therapeutic effects on perioperative thrombocytopenia in the mice with cirrhosis and hypersplenism, who underwent liver transplantation but also significantly enhanced the perioperative liver function.