Observational Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Aug 27, 2022; 14(8): 833-848
Published online Aug 27, 2022. doi: 10.4240/wjgs.v14.i8.833
Early detection of colorectal cancer based on circular DNA and common clinical detection indicators
Jian Li, Tao Jiang, Zeng-Ci Ren, Zhen-Lei Wang, Peng-Jun Zhang, Guo-An Xiang
Jian Li, Guo-An Xiang, The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Jian Li, Guo-An Xiang, Department of General Surgery, Guangdong Second Provincial General Hospital, Guangzhou 510317, Guangdong Province, China
Jian Li, Zeng-Ci Ren, Zhen-Lei Wang, Department of General Surgery, Henan Tumor Hospital, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China
Tao Jiang, Medicine Innovation Research Division of Chinese PLA General Hospital, Beijing 100853, China
Peng-Jun Zhang, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Interventional Therapy Department, Peking University Cancer Hospital and Institute, Beijing 100142, China
Author contributions: Li J and Xian GA designed the study; Li J, Ren ZC and Jiang T performed the research; Li J, Wang ZL and Jiang T analyzed the date; Li J wrote the paper; Xiang GA and Zhang PJ revised the manuscript for final submission; Li J and Jiang T contributed equally to this study; Zhang PJ and Xiang GA the co-corresponding author.
Supported by National Natural Science Foundation of China, No. 81972010; National Key Research and Development Program of China, No. 2020YFC2002700; National Key Research and Development Program of China, No. 2020YFC2004604.
Institutional review board statement: The study was reviewed and approved by the Chinese PLA General Hospital Review Board.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: We declare that we have no financial or personal relationships with other individuals or organizations that can inappropriately influence our work and that there is no professional or other personal interest of any nature in any product, service and/or company that could be construed as influencing the position presented in or the review of the manuscript.
Data sharing statement: No data was to share.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guo-An Xiang, MD, Doctor, The Second School of Clinical Medicine, Southern Medical University, No. 253 Gongye Avenue Haizhu, Guangzhou 510515, Guangdong Province, China. guoanxiang_66@126.com
Received: April 12, 2022
Peer-review started: April 12, 2022
First decision: May 11, 2022
Revised: May 14, 2022
Accepted: August 6, 2022
Article in press: August 6, 2022
Published online: August 27, 2022
Processing time: 134 Days and 1.5 Hours
Core Tip

Core Tip: Most patients with colorectal cancer (CRC) are diagnosed at an advanced stage. The high morbidity and mortality of advanced CRC indicates an urgent need for clinical improvements in early CRC detection and individualized management. Compared with free linear DNA, extrachromosomal circular DNA is not easily degraded by nucleases, and its structure is more stable. In this study, we aimed to build a multi-parameter diagnostic model for early detection of CRC.