Emergency exploratory laparotomy and radical gastrectomy in patients with gastric cancer combined with acute upper gastrointestinal bleeding

ARTICLE HIGHLIGHTS

Research background

Gastric cancer (GC) is a malignant tumor that originates from the gastric mucosal epithelium, and it has the highest incidence rate among various malignant tumors in China. Surgery is the main clinical treatment for GC.

Research motivation

The incidence rate of GC is extremely high, and surgical treatment is the primary approach to curing this disease.

Research objectives

This study aims to explore the clinical value of giving radical surgery and palliative surgery based on exploratory laparotomy in patients with GC combined with upper gastrointestinal bleeding.

Research methods

A total of 89 GC patients were selected and divided into two groups - the palliative group and the radical resection group. The two groups were compared in terms of various indicators such as the operation time, intraoperative blood transfusion, postoperative anal exhaust time, bed time, duodenal stump rupture, anastomotic obstruction complications, and the postoperative immune function, immunoglobulin and tumor markers, inflammatory factors, surgical effect, postoperative quality of life recovery, as well as patient monitoring for postoperative survival and tumor recurrence.

Research results

The radical resection group had shorter intraoperative blood loss and anal exhaust time compared to the palliative group, but did not show a significant difference in the occurrence of postoperative complications. Additionally, the postoperative immune function index and immunoglobulin levels of the radical resection group were higher than those of the palliative group, while the levels of tumor markers and inflammatory factors were lower in the radical resection group. The surgical efficacy and postoperative quality of life of the radical resection group were also higher than those of the palliative group, and the postoperative survival rate was also higher for the radical resection group.

Research conclusions

Laparotomy combined with radical surgery can result in a shorter postoperative hospital stay, improved immune function, increased surgical efficacy, enhanced quality of life recovery, higher survival rate, and reduced chance of tumor recurrence.

Research perspectives

Due to the particularity of GC patients, they must be careful in selecting their treatment approach. Laparotomy combined with radical surgery can effectively enhance surgical efficacy, improve immune function, reduce tumor recurrence rate, and provide a safe and controllable treatment option. Therefore, this approach is worth promoting and applying. On the premise of strictly controlling the indications, laparotomy combined with radical surgery should be selected whenever possible.