Bertol FS, Araujo B, Jorge BB, Rinaldi N, De Carli LA, Tovo CV. Role of micronutrients in staging of nonalcoholic fatty liver disease: A retrospective cross-sectional study. World J Gastrointest Surg 2020; 12(6): 269-276 [PMID: 32774765 DOI: 10.4240/wjgs.v12.i6.269]
Corresponding Author of This Article
Cristiane Valle Tovo, MD, PhD, Adjunct Professor, Graduate Program of Medicine, Hepatology, Universidade Federal de Ciências da Saúde de Porto Alegre, Rua Sarmento Leite 245, Porto Alegre, RS 90430080, Brazil. cristianev@ufcspa.edu.br
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Jun 27, 2020; 12(6): 269-276 Published online Jun 27, 2020. doi: 10.4240/wjgs.v12.i6.269
Role of micronutrients in staging of nonalcoholic fatty liver disease: A retrospective cross-sectional study
Franciele Sabadin Bertol, Bruna Araujo, Brunno Brochado Jorge, Natalino Rinaldi, Luiz Alberto De Carli, Cristiane Valle Tovo
Franciele Sabadin Bertol, Bruna Araujo, Brunno Brochado Jorge, Natalino Rinaldi, Luiz Alberto De Carli, Cristiane Valle Tovo, Graduate Program of Medicine, Hepatology, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS 90430080, Brazil
Author contributions: Tovo CV conceptualized the manuscript; Bertol FS, Araujo B and Jorge BB collected the data; Bertol FS and Tovo CV wrote the manuscript; All authors helped to perform the research, performed the final review with significant contributions, and approved the final version of the manuscript.
Institutional review board statement: This study agrees with resolution 466 of 2012, which governs the conduct of human subjects research, and was approved by the Research Ethics Committee of the institution concerned (opinion number 982.654).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available. Data used and/or analyzed during this study are available upon request to the author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Cristiane Valle Tovo, MD, PhD, Adjunct Professor, Graduate Program of Medicine, Hepatology, Universidade Federal de Ciências da Saúde de Porto Alegre, Rua Sarmento Leite 245, Porto Alegre, RS 90430080, Brazil. cristianev@ufcspa.edu.br
Received: December 15, 2019 Peer-review started: December 15, 2019 First decision: April 2, 2020 Revised: April 10, 2020 Accepted: May 5, 2020 Article in press: May 5, 2020 Published online: June 27, 2020 Processing time: 186 Days and 11.7 Hours
ARTICLE HIGHLIGHTS
Research background
It has been suggested that some micronutrients would have antioxidant potential and could reduce the accumulation of reactive oxygen species, consequently delaying or preventing the evolution of nonalcoholic fatty liver disease (NAFLD).
Research motivation
Identify potential new therapeutic strategies for NAFLD.
Research objectives
Evaluate the relationship between serum levels of micronutrients and the severity of NAFLD.
Research methods
A retrospective, observational, and cross-sectional study was conducted. This study included patients undergoing bariatric surgery at a reference center in southern Brazil. These patients underwent liver biopsy during the procedure and had serum levels of micronutrients assessed in a preoperative evaluation.
Research results
Serum levels of vitamin D were negatively correlated with the severity of steatosis and nonalcoholic steatohepatitis, and serum levels of vitamin B12 were positively correlated with the severity of steatosis and fibrosis.
Research conclusions
Serum levels of vitamin D are inversely related to the severity of steatosis and nonalcoholic steatohepatitis, and serum levels of vitamin B12 are higher in more advanced stages of simple steatosis and liver fibrosis.
Research perspectives
Further studies should be done to assess the relationship of micronutrients and NAFLD.
