Zhu LL, Shen RZ. Follow-up of elderly gastric cancer post-radical surgery: Trauma, complications, and prognosis. World J Gastrointest Surg 2025; 17(3): 100143 [DOI: 10.4240/wjgs.v17.i3.100143]
Corresponding Author of This Article
Rui-Zhi Shen, Department of Oncology, Jiangnan University Medical Center, No. 68 Zhongshan Road, Liangxi District, Wuxi 214001, Jiangsu Province, China. 497838685@qq.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Clinical Trials Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Mar 27, 2025; 17(3): 100143 Published online Mar 27, 2025. doi: 10.4240/wjgs.v17.i3.100143
Follow-up of elderly gastric cancer post-radical surgery: Trauma, complications, and prognosis
Li-Ling Zhu, Rui-Zhi Shen
Li-Ling Zhu, Department of Geriatrics, Jiangnan University Medical Center, Wuxi 214001, Jiangsu Province, China
Rui-Zhi Shen, Department of Oncology, Jiangnan University Medical Center, Wuxi 214001, Jiangsu Province, China
Author contributions: Zhu LL designed the study; Zhu LL and Shen RZ analyzed the data, involved in the data collection and writing of this article; All the authors have read and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of Jiangnan University Medical Center Ethical review batch number: (2024) Ethics Review No. Y-231.
Clinical trial registration statement: Clinical trials registered in research registry: No. Researchregistry10914.
Informed consent statement: All study participants and their legal guardians provided written informed consent before enrolment.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rui-Zhi Shen, Department of Oncology, Jiangnan University Medical Center, No. 68 Zhongshan Road, Liangxi District, Wuxi 214001, Jiangsu Province, China. 497838685@qq.com
Received: November 13, 2024 Revised: December 16, 2024 Accepted: January 2, 2025 Published online: March 27, 2025 Processing time: 102 Days and 18.6 Hours
Abstract
BACKGROUND
The incidence of gastric cancer in the elderly is increasing; however, standardized surgical approaches are lacking.
AIM
To investigate the effects of radical surgery on the trauma response, postoperative complications, and long-term prognosis in elderly patients with gastric cancer.
METHODS
Between January 2020 and December 2023, 110 gastric cancer patients admitted to the Department of Oncology Jiangnan University Medical Center were categorized into a control group (40 cases) and an observation group (70 cases) based on surgical method differences. The control and observation group received palliative surgery and radical surgery, respectively, and were further divided into open (25 cases) and laparoscopic (45 cases) surgery. Surgical outcomes, trauma indicators, complication rates, and long-term survival at 6 months, 1-, and 2-years were compared.
RESULTS
Laparoscopic surgery showed superior surgical outcomes compared to the open surgery and control groups (P < 0.05). Trauma indicators were lowest in the laparoscopic group and highest in the control group (P < 0.05). No significant difference was observed in the complication rates between the open and laparoscopic groups (P > 0.05), but both were higher than those in the control group (P < 0.05). No significant differences were found in survival rates at different follow-up periods between the laparoscopic and open groups (P > 0.05); however, both groups showed higher survival rates than the control group (P < 0.05).
CONCLUSION
Radical surgery in elderly patients with gastric cancer reduces surgical trauma response, facilitates postoperative recovery, and improves long-term survival rates, albeit with an increased risk of complications. Laparoscopic radical surgery further minimizes postoperative trauma, with no significant difference in complication rates and survival prognosis compared with open radical surgery.
Core Tip: Although elderly patients have reduced surgical tolerance, surgery remains the primary treatment for gastric cancer in this population. Selecting appropriate surgical methods can reduce mortality and enhance the quality of life in elderly patients with gastric cancer.
