Zhang L, Yang WF, Wu HD, Zhu HH. Risk factors analysis for poor prognosis after percutaneous drainage in liver abscess patients with fatty liver. World J Gastrointest Surg 2025; 17(10): 110836 [PMID: 41178858 DOI: 10.4240/wjgs.v17.i10.110836]
Corresponding Author of This Article
Hui-Hui Zhu, MD, Department of Emergency, Tongde Hospital of Zhejiang Province, No. 234 Gucui Road, Hangzhou 310012, Zhejiang Province, China. 17805819776@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Oct 27, 2025; 17(10): 110836 Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.110836
Risk factors analysis for poor prognosis after percutaneous drainage in liver abscess patients with fatty liver
Li Zhang, Wen-Fei Yang, Hong-Di Wu, Hui-Hui Zhu
Li Zhang, Wen-Fei Yang, Hong-Di Wu, Department of Infectious Diseases, Tongde Hospital of Zhejiang Province, Hangzhou 310012, Zhejiang Province, China
Hui-Hui Zhu, Department of Emergency, Tongde Hospital of Zhejiang Province, Hangzhou 310012, Zhejiang Province, China
Author contributions: Zhang L and Zhu HH conceived and designed the study; Zhang L, Yang WF, and Wu HD collected and analyzed the clinical data; Zhang L and Yang WF performed the statistical analysis and interpreted the results; Zhang L drafted the manuscript, and all authors contributed to manuscript revision and approved the final version for publication.
Supported by Zhejiang Province Traditional Chinese Medicine Science and Technology Plan Project, No. 2024ZL039.
Institutional review board statement: This study was reviewed and approved by the Medical Ethics Committee of Tongde Hospital of Zhejiang Province (Approval No. 2024-094-JY).
Informed consent statement: The requirement for signed informed consent was waived due to the retrospective design and anonymized nature of the data.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest related to this study.
Data sharing statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hui-Hui Zhu, MD, Department of Emergency, Tongde Hospital of Zhejiang Province, No. 234 Gucui Road, Hangzhou 310012, Zhejiang Province, China. 17805819776@163.com
Received: July 8, 2025 Revised: August 9, 2025 Accepted: August 22, 2025 Published online: October 27, 2025 Processing time: 107 Days and 23.8 Hours
Abstract
BACKGROUND
Liver abscess is a serious hepatic infectious disease for which percutaneous drainage has become the preferred treatment method due to its minimally invasive advantages. With the rising prevalence of non-alcoholic fatty liver disease reaching 29.2% in Chinese adults, the number of patients with liver abscess combined with fatty liver has shown a significant increasing trend clinically.
AIM
To analyze risk factors affecting prognosis after percutaneous drainage in liver abscess patients with fatty liver.
METHODS
A retrospective analysis of 165 liver abscess patients with fatty liver who underwent percutaneous drainage from January 2020 to April 2024. Patients were divided into good prognosis (n = 121, 73.3%) and poor prognosis groups (n = 44, 26.7%) based on 30-day outcomes. Univariate and multivariate logistic regression analyses were performed to identify independent risk factors.
RESULTS
The poor prognosis group had older age (65.2 ± 11.8 years vs 56.1 ± 11.9 years, P < 0.001), higher diabetes prevalence (70.5% vs 47.2%, P = 0.008), elevated inflammatory markers, and lower serum albumin (26.8 ± 4.2 g/L vs 32.1 ± 5.6 g/L, P < 0.001). Moderate-to-severe fatty liver was more prevalent in the poor prognosis group (68.2% vs 38.0%, P = 0.001). Multivariate analysis identified five independent risk factors: Age ≥ 65 years (OR = 2.847, P = 0.007), diabetes history (OR = 3.124, P = 0.003), abscess diameter ≥ 8 cm (OR = 2.591, P = 0.015), serum albumin < 30 g/L (OR = 3.456, P = 0.001), and moderate-to-severe fatty liver (OR = 2.213, P = 0.035).
CONCLUSION
Advanced age, diabetes history, large abscess, hypoalbuminemia, and moderate-to-severe fatty liver are independent risk factors for poor prognosis after percutaneous drainage in liver abscess patients with fatty liver.
