Korkusuz M, Et T. Effect of perioperative restrictive and liberal fluid regimens on postoperative nausea-vomiting and quality of recovery in laparoscopic cholecystectomy. World J Gastrointest Surg 2025; 17(10): 110543 [DOI: 10.4240/wjgs.v17.i10.110543]
Corresponding Author of This Article
Muhammet Korkusuz, MD, Affiliate Associate Professor, Department of Anesthesiology and Reanimation, School of Medicine, Karamanoglu Mehmetbey University, University Neighborhood, 1984th Street, Karaman 70100, Türkiye. drmuhammetkorkusuz@gmail.com
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Anesthesiology
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Randomized Controlled Trial
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Oct 27, 2025 (publication date) through Oct 24, 2025
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World Journal of Gastrointestinal Surgery
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1948-9366
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Korkusuz M, Et T. Effect of perioperative restrictive and liberal fluid regimens on postoperative nausea-vomiting and quality of recovery in laparoscopic cholecystectomy. World J Gastrointest Surg 2025; 17(10): 110543 [DOI: 10.4240/wjgs.v17.i10.110543]
World J Gastrointest Surg. Oct 27, 2025; 17(10): 110543 Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.110543
Effect of perioperative restrictive and liberal fluid regimens on postoperative nausea-vomiting and quality of recovery in laparoscopic cholecystectomy
Muhammet Korkusuz, Tayfun Et
Muhammet Korkusuz, Tayfun Et, Department of Anesthesiology and Reanimation, School of Medicine, Karamanoglu Mehmetbey University, Karaman 70100, Türkiye
Author contributions: Korkusuz M and Et T performed the experimental investigation, formal data analysis, provided resources for the study, and supervised the study; Korkusuz M conceptualized the study, designed the methodology, generated the visualization of the data, and wrote the original draft of the manuscript; Et T performed the data curation and validation of the findings, and reviewed and edited all versions of the manuscript; both authors read and approved the final version of the manuscript.
Institutional review board statement: This study is approved by the Karamanoglu Mehmetbey University Faculty of Medicine Ethics Committee, No. 10-2023/14.
Clinical trial registration statement: This study was registered at clinicaltrials.gov. The registration identification number is NCT06197659.
Informed consent statement: All study participants and their legal guardians provided written informed consent before recruitment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: The data is available upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Muhammet Korkusuz, MD, Affiliate Associate Professor, Department of Anesthesiology and Reanimation, School of Medicine, Karamanoglu Mehmetbey University, University Neighborhood, 1984th Street, Karaman 70100, Türkiye. drmuhammetkorkusuz@gmail.com
Received: June 10, 2025 Revised: June 27, 2025 Accepted: August 6, 2025 Published online: October 27, 2025 Processing time: 137 Days and 12.8 Hours
Abstract
BACKGROUND
Postoperative nausea-vomiting (PONV) occurs often after surgery performed under general anesthesia. Liberal fluid treatments are a low-cost and a low side-effect alternative to pharmacological treatment in the prevention of PONV.
AIM
To compare the effects of perioperative liberal and restrictive fluid therapy on PONV and recovery after laparoscopic cholecystectomy.
METHODS
A total of 160 patients were randomly allocated to two groups: Liberal fluid treatment group (group L), and restrictive fluid treatment group (group R). Three patients were excluded. Ringer’s lactate infusion was administered intravenously as follows: 20 mL/kg/hour to group L, and 4 mL/kg/hour to group R. The primary outcomes were PONV incidence 24 hours postoperatively and the quality of recovery-15 scale at 24 hours postoperatively.
RESULTS
The incidence of PONV was significantly lower in group L (38.0%) compared with group R (70.5%) (relative risk: 0.54, 95% confidence interval: 0.39-0.74, P < 0.001). The quality of recovery-15 scale scores for overall satisfaction were significantly higher in group L compared with group R [137 (135-141) vs 135 (130-139), P = 0.006].
CONCLUSION
Perioperative liberal fluid therapy reduced the incidence of PONV and improved the quality of postoperative recovery in patients undergoing laparoscopic cholecystectomy.
Core Tip: Liberal fluid therapy may be an alternative to pharmacological therapy in the prevention of postoperative nausea-vomiting (PONV) because of its low cost and few side effects. This study investigated the effect of liberal fluid therapy and restrictive fluid therapy in the prevention of PONV after laparoscopic cholecystectomy. Perioperative liberal fluid therapy reduced the incidence of PONV and improved the quality of postoperative recovery in patients undergoing laparoscopic cholecystectomy.
