Zhu N, Chen MY, Li KQ, Zhang YM, Li FL, Li P, Wu J, Zou BC. Subtotal resection of gastric duplication cysts using endoscopic submucosal dissection: A case report. World J Gastrointest Surg 2025; 17(10): 110540 [PMID: 41178846 DOI: 10.4240/wjgs.v17.i10.110540]
Corresponding Author of This Article
Bai-Cang Zou, PhD, Chief Physician, Professor, Department of Gastroenterology, The Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 West Fifth Road, Xi’an 710004, Shaanxi Province, China. zoubaicang2@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Oct 27, 2025 (publication date) through Nov 15, 2025
Times Cited of This Article
Times Cited (0)
Journal Information of This Article
Publication Name
World Journal of Gastrointestinal Surgery
ISSN
1948-9366
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Zhu N, Chen MY, Li KQ, Zhang YM, Li FL, Li P, Wu J, Zou BC. Subtotal resection of gastric duplication cysts using endoscopic submucosal dissection: A case report. World J Gastrointest Surg 2025; 17(10): 110540 [PMID: 41178846 DOI: 10.4240/wjgs.v17.i10.110540]
World J Gastrointest Surg. Oct 27, 2025; 17(10): 110540 Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.110540
Subtotal resection of gastric duplication cysts using endoscopic submucosal dissection: A case report
Ning Zhu, Meng-Yao Chen, Ke-Qing Li, Yuan-Miao Zhang, Fang-Lan Li, Peng Li, Jie Wu, Bai-Cang Zou
Ning Zhu, Meng-Yao Chen, Ke-Qing Li, Yuan-Miao Zhang, Bai-Cang Zou, Department of Gastroenterology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
Fang-Lan Li, Department of Gastroenterology, Yan’an University Xianyang Hospital, Xianyang 712000, Shaanxi Province, China
Peng Li, Department of Pediatric Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
Jie Wu, Department of Pathology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
Co-first authors: Ning Zhu and Meng-Yao Chen.
Author contributions: Zhu N and Chen MY wrote the manuscript, and they contributed equally to this manuscript and are co-first authors; Li KQ, Zhang YM, and Li FL conceptualized the study; Li P and Zou BC designed the study and critically revised the manuscript for important intellectual content; Wu J provided pathological expertise. All authors read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bai-Cang Zou, PhD, Chief Physician, Professor, Department of Gastroenterology, The Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 West Fifth Road, Xi’an 710004, Shaanxi Province, China. zoubaicang2@163.com
Received: June 12, 2025 Revised: July 12, 2025 Accepted: September 3, 2025 Published online: October 27, 2025 Processing time: 134 Days and 19 Hours
Abstract
BACKGROUND
Gastric duplication cysts (GDCs) are rare congenital anomalies, and consensus guidelines for their diagnosis and management are currently lacking. We report a rare case of a GDC in a female child presenting as a submucosal tumor in the gastric antrum. Subtotal resection was achieved using endoscopic submucosal dissection (ESD), resulting in complete symptom relief and pathological confirmation. This case demonstrates the therapeutic potential of ESD for intraluminal GDCs and underscores the importance of complete resection for definitive diagnosis.
CASE SUMMARY
A 12-year-old girl presented with abdominal distension and pain for > 1 year. Gastroscopy revealed a protruding lesion approximately 30 mm in diameter in the gastric antrum. Superficial biopsies revealed moderate chronic inflammation and intestinal metaplasia. Contrast-enhanced computed tomography showed a mass protruding into the gastric lumen with homogeneous cyst wall enhancement. Endoscopic ultrasonography identified a hypoechoic mass originating from the muscularis mucosa. The patient underwent ESD for diagnosis and symptom relief. Intraoperatively, due to firm adhesion between the cyst base and the muscularis propria, selective preservation of the adherent cyst base was performed to mitigate perforation and stenosis risks. Histopathology confirmed a GDC, with cyst lumen lined by gastric-type columnar epithelium and an outer smooth muscle layer. Focal ectopic pancreatic tissues were identified. The patient recovered without complications and remained asymptomatic during 6-month follow-up. Repeat gastroscopy showed the residual cyst wall conforming to antral mucosa, with no recurrence.
CONCLUSION
Subtotal resection of GDCs using ESD demonstrates a favorable prognosis.
Core Tip: This study is the first to explore the efficacy of endoscopic submucosal dissection for subtotal resection of intraluminal gastric duplication cyst (GDC). Following near-total resection of an antral submucosal tumor using endoscopic submucosal dissection in a 12-year-old girl, symptoms completely resolved, and histopathology confirmed a GDC. We emphasize the importance of complete resection for definitive diagnosis, while 6-month follow-up confirmed that residual cyst wall preservation had no adverse impact on short-term prognosis. This finding points to a new, safe, and effective minimally invasive therapeutic strategy for GDCs.
