Systematic Reviews
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Dec 27, 2021; 13(12): 1754-1769
Published online Dec 27, 2021. doi: 10.4240/wjgs.v13.i12.1754
Current and future role of three-dimensional modelling technology in rectal cancer surgery: A systematic review
Anna Przedlacka, Gianluca Pellino, Jordan Fletcher, Fernando Bello, Paris P Tekkis, Christos Kontovounisios
Anna Przedlacka, Paris P Tekkis, Christos Kontovounisios, Department of Surgery and Cancer, Imperial College London, London SW10 9NH, United Kingdom
Gianluca Pellino, Department of Advanced Medical and Surgical Sciences, Università degli Studi della Campania “Luigi Vanvitelli”, Naples 80138, Campania, Italy
Gianluca Pellino, Colorectal Surgery, Vall d'Hebron University Hospital, Barcelona 08029, Spain
Gianluca Pellino, Paris P Tekkis, Christos Kontovounisios, Colorectal Surgery, Royal Marsden NHS Foundation Trust, London SW3 6JJ, United Kingdom
Jordan Fletcher, Department of Surgery and Cancer, St Mark’s Hospital Academic Institute, Imperial College London, London HA1 3UJ, United Kingdom
Fernando Bello, Centre for Engagement and Simulation Science, Imperial College London, London SW10 9NH, United Kingdom
Paris P Tekkis, Christos Kontovounisios, Colorectal Surgery, Chelsea and Westminster Hospital NHS Foundation Trust, London SW10 9NH, United Kingdom
Author contributions: Przedlacka A designed the research; Przedlacka A and Fletcher J performed the data search and screening; Przedlacka A, Pellino G and Kontovounisios C analysed the data; Przedlacka A drafted the manuscript; Pellino G, Kontovounisios C, Bello F and Tekkis PP revised the manuscript; All authors approved the final manuscript.
Conflict-of-interest statement: All the authors declare that they have no competing interests.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gianluca Pellino, MD, PhD, FRCS (Gen Surg), FEBS (Coloproctology), FASCRS, FACS, Department of Advanced Medical and Surgical Sciences, Università degli Studi della Campania “Luigi Vanvitelli”, Piazza Miraglia 2, Naples 80138, Campania. gianluca.pellino@unicampania.it
Received: April 28, 2021
Peer-review started: April 28, 2021
First decision: June 17, 2021
Revised: June 9, 2021
Accepted: November 15, 2021
Article in press: November 15, 2021
Published online: December 27, 2021
Processing time: 239 Days and 16.4 Hours
Abstract
BACKGROUND

Three-dimensional (3D) modelling technology translates the patient-specific anatomical information derived from two-dimensional radiological images into virtual or physical 3D models, which more closely resemble the complex environment encountered during surgery. It has been successfully applied to surgical planning and navigation, as well as surgical training and patient education in several surgical specialties, but its uptake lags behind in colorectal surgery. Rectal cancer surgery poses specific challenges due to the complex anatomy of the pelvis, which is difficult to comprehend and visualise.

AIM

To review the current and emerging applications of the 3D models, both virtual and physical, in rectal cancer surgery.

METHODS

Medline/PubMed, Embase and Scopus databases were searched using the keywords “rectal surgery”, “colorectal surgery”, “three-dimensional”, “3D”, “modelling”, “3D printing”, “surgical planning”, “surgical navigation”, “surgical education”, “patient education” to identify the eligible full-text studies published in English between 2001 and 2020. Reference list from each article was manually reviewed to identify additional relevant papers. The conference abstracts, animal and cadaveric studies and studies describing 3D pelvimetry or radiotherapy planning were excluded. Data were extracted from the retrieved manuscripts and summarised in a descriptive way. The manuscript was prepared and revised in accordance with PRISMA 2009 checklist.

RESULTS

Sixteen studies, including 9 feasibility studies, were included in the systematic review. The studies were classified into four categories: feasibility of the use of 3D modelling technology in rectal cancer surgery, preoperative planning and intraoperative navigation, surgical education and surgical device design. Thirteen studies used virtual models, one 3D printed model and 2 both types of models. The construction of virtual and physical models depicting the normal pelvic anatomy and rectal cancer, was shown to be feasible. Within the clinical context, 3D models were used to identify vascular anomalies, for surgical planning and navigation in lateral pelvic wall lymph node dissection and in management of recurrent rectal cancer. Both physical and virtual 3D models were found to be valuable in surgical education, with a preference for 3D printed models. The main limitations of the current technology identified in the studies were related to the restrictions of the segmentation process and the lack of 3D printing materials that could mimic the soft and deformable tissues.

CONCLUSION

3D modelling technology has potential to be utilised in multiple aspects of rectal cancer surgery, however, it is still at the experimental stage of application in this setting.

Keywords: Rectal cancer; Three-dimensional modelling; Three-dimensional printing; Image-guided surgery; Surgical navigation; Surgical education

Core Tip: Three-dimensional (3D) modelling technology has revolutionized preoperative planning, intraoperative navigation, and surgical training in several surgical specialties. Rectal cancer surgery poses significant challenges due to the complex anatomy of the pelvis. While there is marked interest in the application of 3D modelling in this field, it appears to be still in its relative infancy. Future research and technological developments will enable clinical application of the virtual and physical 3D models to enhance surgical vision before and during rectal cancer surgery.