Comparison of three types of drugs for cardiovascular and renal benefits in type 2 diabetes mellitus

Figure 1 Literature search and screening flowchart. RCT: Randomized controlled trial.

Figure 2 Results of major adverse cardiovascular events. A: Comparison network results for major adverse cardiovascular events (MACEs) of three classes of drugs; B: Comparison network results for MACEs of different drugs; C: Forest plot for MACEs of three classes of drugs; D: Forest plot for MACEs of different drugs.

Figure 3 Results of all-cause mortality. A: Comparison network results for all-cause mortality of three classes of drugs; B: Comparison network results for all-cause mortality of different drugs; C: Forest plot for all-cause mortality of three classes of drugs; D: Forest plot for all-cause mortality of different drugs.

Figure 4 Results of cardiovascular mortality. A: Comparison network results for cardiovascular mortality of three classes of drugs; B: Comparison network results for cardiovascular mortality of different drugs; C: Forest plot for cardiovascular mortality of three classes of drugs; D: Forest plot for cardiovascular mortality of different drugs.

Figure 5 Results of composite renal events. A: Comparison network results for composite renal events of three classes of drugs; B: Comparison network results for composite renal events of different drugs; C: Forest plot for composite renal events of three classes of drugs; D: Forest plot for composite renal events of different drugs.

Figure 6 Results of progression of proteinuria. A: Comparison network results for progression of proteinuria of three classes of drugs; B: Comparison network results for progression of proteinuria of different drugs; C: Forest plot for progression of proteinuria of three classes of drugs; D: Forest plot for progression of proteinuria of different drugs.

Figure 7 Results of renal replacement therapy. A: Comparison network results for renal replacement therapy of three classes of drugs; B: Comparison network results for renal replacement therapy of different drugs; C: Forest plot for renal replacement therapy of three classes of drugs; D: Forest plot for renal replacement therapy of different drugs.

Figure 8 Results of serious adverse events. A: Comparison network results for serious adverse events of three classes of drugs; B: Comparison network results for serious adverse events of different drugs; C: Forest plot for serious adverse events of three classes of drugs; D: Forest plot for serious adverse events of different drugs.

Figure 9 Results of diabetic ketoacidosis. A: Comparison network results for diabetic ketoacidosis of three classes of drugs; B: Comparison network results for diabetic ketoacidosis of different drugs; C: Forest plot for diabetic ketoacidosis of three classes of drugs; D: Forest plot for diabetic ketoacidosis of different drugs.

Figure 10  Results of pancreatitis. A: Comparison network results for pancreatitis of three classes of drugs; B: Comparison network results for pancreatitis of different drugs; C: Forest plot for pancreatitis of three classes of drugs; D: Forest plot for pancreatitis of different drugs.