Lovrenčić MV, Biljak VR, Blaslov K, Božičević S, Duvnjak LS. Impact of creatinine methodology on glomerular filtration rate estimation in diabetes. World J Diabetes 2017; 8(5): 222-229 [PMID: 28572883 DOI: 10.4239/wjd.v8.i5.222]
Corresponding Author of This Article
Marijana Vučić Lovrenčić, PhD, Department of Laboratory Medicine, Merkur University Hospital, Zajčeva 19, HR-10000 Zagreb, Croatia. vucic@idb.hr
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Marijana Vučić Lovrenčić, Vanja Radišić Biljak, Sandra Božičević, Department of Laboratory Medicine, Merkur University Hospital, HR-10000 Zagreb, Croatia
Kristina Blaslov, Lea Smirčić Duvnjak, Vuk Vrhovac University Clinic, Merkur University Hospital, HR-10000 Zagreb, Croatia
Author contributions: Lovrenčić MV designed the study and wrote the article; Biljak VR and Lovrenčić MV analyzed the data, Biljak VR and Božičević B performed the laboratory part of the study; Blaslov K and Duvnjak LS performed the clinical part of the study; all authors discussed the results and approved the final version of the manuscript.
Institutional review board statement: The study was approved by the Ethics Committee of the Merkur University Hospital, Zagreb, Croatia.
Informed consent statement: This study was waived by IRB due to the retrospective nature of the study, with the post-hoc selection of anonymized samples from the routine laboratory visits, according to creatinine and glucose results.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article are reported.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Marijana Vučić Lovrenčić, PhD, Department of Laboratory Medicine, Merkur University Hospital, Zajčeva 19, HR-10000 Zagreb, Croatia. vucic@idb.hr
Telephone: +385-1-2353861 Fax: +385-1-2353847
Received: October 29, 2016 Peer-review started: November 2, 2016 First decision: December 1, 2016 Revised: December 20, 2016 Accepted: February 28, 2017 Article in press: March 2, 2017 Published online: May 15, 2017 Processing time: 198 Days and 5.8 Hours
Core Tip
Core tip: Analytical performance of the serum creatinine assays is the critical determinant of estimated glomerular filtration rate (eGFR) accuracy. The most widely used compensated Jaffé creatinine assay suffers from a non-specific bias from pseudo-creatinine chromogens (glucose, ketones), which is not the case with the costly enzymatic assays. We evaluated the influence of creatinine methodology on the performance of chronic kidney disease (CKD)-Epidemiology-calculated eGFR for CKD diagnosis/staging in diabetic patients. Our results indicate that compensated Jaffé creatinine procedure, in spite of the glucose-dependent bias, is not inferior to enzymatic creatinine in CKD diagnosis/staging and therefore may provide a reliable and cost-effective tool for the renal function assessment in diabetic patients.
