Talaei M, Pan A. Role of phytoestrogens in prevention and management of type 2 diabetes. World J Diabetes 2015; 6(2): 271-283 [PMID: 25789108 DOI: 10.4239/wjd.v6.i2.271]
Corresponding Author of This Article
An Pan, PhD, Department of Epidemiology and Biostatistics, MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan 430030, Hubei Province, China. panan@hust.edu.cn
Research Domain of This Article
Nutrition & Dietetics
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Mar 15, 2015; 6(2): 271-283 Published online Mar 15, 2015. doi: 10.4239/wjd.v6.i2.271
Role of phytoestrogens in prevention and management of type 2 diabetes
Mohammad Talaei, An Pan
Mohammad Talaei, An Pan, Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore
An Pan, Department of Epidemiology and Biostatistics, MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Author contributions: Talaei M and Pan A contributed to this paper.
Conflict-of-interest: The authors declare no conflicts of interest regarding this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: An Pan, PhD, Department of Epidemiology and Biostatistics, MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan 430030, Hubei Province, China. panan@hust.edu.cn
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Received: September 21, 2014 Peer-review started: September 22, 2014 First decision: October 16, 2014 Revised: November 4, 2014 Accepted: December 16, 2014 Article in press: December 17, 2014 Published online: March 15, 2015 Processing time: 179 Days and 2 Hours
Core Tip
Core tip: Phytoestrogens are a group of polyphenols that are structurally similar to endogenous estrogen. Animal experiments and pre-clinical models have provided strong evidence that phytoestrogens may have anti-diabetic function via both estrogen-dependent and estrogen-independent pathways. A number of epidemiological studies and clinical trials have thus been conducted in different populations linking two major types of phytoestrogens, isoflavones and lignans, to the prevention and management of diabetes. Although the current evidence is complex and inconsistent, habitual consumption of phytoestrogens, particularly their intact food sources, could be considered as a component of overall healthy dietary pattern for prevention and management of diabetes.
