Letter to the Editor: Dynamic SERCA regulation and early metabolic dysfunction in young adults with high waist-to-height ratio

doi:10.4239/wjd.123444

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. Sep 15, 2026; 17(9): 123444
Published online Sep 15, 2026. doi: 10.4239/wjd.123444

Letter to the Editor: Dynamic SERCA regulation and early metabolic dysfunction in young adults with high waist-to-height ratio

Zhi-Peng Zhou

Zhi-Peng Zhou, Department of Integrated Traditional Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, Fujian Province, China

Author contributions: Zhou ZP conceptualized the commentary, performed the literature review, and wrote the manuscript and he have read and approved the final version of the manuscript.

AI contribution statement: Portions of this manuscript were edited using AI tools solely for language refinement. The authors carefully reviewed and verified all AI-assisted outputs and take full responsibility for the scientific content of the manuscript.

Conflict-of-interest statement: The authors have no potential conflicts of interest to disclose.

Corresponding author: Zhi-Peng Zhou, Department of Integrated Traditional Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine, No. 1 Qiuyang Road, Fuzhou 350122, Fujian Province, China. zhouzhipengl@163.com

Received: May 19, 2026
Revised: July 1, 2026
Accepted: July 14, 2026
Published online: September 15, 2026
Processing time: 104 Days and 9.1 Hours

Core Tip

Core Tip: This commentary extends the findings of Casillas et al. It discusses the biphasic regulation of SERCA as a key determinant of disease progression. It emphasizes the unrecognized metabolic risk in young adults with elevated waist-to-height ratio. It also highlights the cross-disease implications of endoplasmic reticulum stress and JNK activation. These perspectives provide important insights for early risk stratification and mechanism-based interventions.