Casillas OE, Hernández-Aguirre CA, Leija-Montoya AG, Romero-García T, Vázquez-Jiménez JG. Association between high waist-height ratio and endoplasmic reticulum stress of young adults with insulin resistance. World J Diabetes 2026; 17(5): 116053 [DOI: 10.4239/wjd.v17.i5.116053]
Corresponding Author of This Article
J Gustavo Vázquez-Jiménez, MD, PhD, Department of Physiology, Faculty of Medicine and Nutrition, Autonomous University of Baja California, Centro Cívico, Mexicali 21000, Baja California, Mexico. gustavo.vazquez@uabc.edu.mx
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Endocrinology & Metabolism
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Basic Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
May 15, 2026 (publication date) through May 14, 2026
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Journal Information of This Article
Publication Name
World Journal of Diabetes
ISSN
1948-9358
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Casillas OE, Hernández-Aguirre CA, Leija-Montoya AG, Romero-García T, Vázquez-Jiménez JG. Association between high waist-height ratio and endoplasmic reticulum stress of young adults with insulin resistance. World J Diabetes 2026; 17(5): 116053 [DOI: 10.4239/wjd.v17.i5.116053]
World J Diabetes. May 15, 2026; 17(5): 116053 Published online May 15, 2026. doi: 10.4239/wjd.v17.i5.116053
Association between high waist-height ratio and endoplasmic reticulum stress of young adults with insulin resistance
Oscar E Casillas, César A Hernández-Aguirre, Ana Gabriela Leija-Montoya, Tatiana Romero-García, J Gustavo Vázquez-Jiménez
Oscar E Casillas, César A Hernández-Aguirre, Ana Gabriela Leija-Montoya, J Gustavo Vázquez-Jiménez, Department of Physiology, Faculty of Medicine and Nutrition, Autonomous University of Baja California, Mexicali 21000, Baja California, Mexico
Tatiana Romero-García, Blood Chemistry Laboratory, Faculty of Sports, Autonomous University of Baja California, Mexicali 21289, Baja California, Mexico
Author contributions: Casillas OE and Vázquez-Jiménez JG conceptualized the study, designed the methodology and performed the analysis; Leija-Montoya AG, Casillas OE and Hernández-Aguirre CA performed the research; Leija-Montoya AG, Romero-García T, and Vázquez-Jiménez JG performed the data curation; Casillas OE, Romero-García T, and Vázquez-Jiménez JG wrote the original draft; Romero-García T, and Vázquez-Jiménez JG reviewed and edited the manuscript; Vázquez-Jiménez JG received the funding; all authors have read and agreed to the published version of the manuscript.
Supported by Program of Universidad Autónoma de Baja California, No. 106/2/C/27/25.
Institutional review board statement: The study was reviewed and approved by the Autonomous University of Baja California, Sports Faculty-Ethics Committee (Approval No. 265/2023-1).
Conflict-of-interest statement: All the authors report having no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Corresponding author: J Gustavo Vázquez-Jiménez, MD, PhD, Department of Physiology, Faculty of Medicine and Nutrition, Autonomous University of Baja California, Centro Cívico, Mexicali 21000, Baja California, Mexico. gustavo.vazquez@uabc.edu.mx
Received: November 2, 2025 Revised: December 12, 2025 Accepted: January 30, 2026 Published online: May 15, 2026 Processing time: 191 Days and 15.2 Hours
Core Tip
Core Tip: Insulin resistance (IR), a health complication commonly associated with advanced age, is increasingly affecting the young population due to poor eating habits and a sedentary lifestyle. In this study, conducted with 39 young adults, participants with a waist-to-height ratio greater than 0.5 showed elevated insulin levels, higher Homeostatic Model Assessment of Insulin Resistance, and altered body composition. Likewise, these participants exhibited platelet molecular disturbances, including IR and activation of proteins associated with endoplasmic reticulum stress. The results suggest that excessive central adiposity in the young population triggers early activation of molecular mechanisms underlying the development of metabolic diseases, such as type 2 diabetes mellitus.
