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World J Diabetes. Apr 15, 2026; 17(4): 114061
Published online Apr 15, 2026. doi: 10.4239/wjd.v17.i4.114061
Published online Apr 15, 2026. doi: 10.4239/wjd.v17.i4.114061
C1q tumor necrosis factor associated protein 3 protects HaCaT via phosphoinositide 3-kinase/protein kinase B activation by PTEN reduction
Lin He, Xue-Yuan Yu, Hui-Cong Dou, Mao-Guo Shu, Department of Plastic, Aesthetic and Maxillofacial Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Chan Zhu, Department of Burns and Cutaneous Surgery, Xijing Hospital, Air Force Medical University, Xi’an 710032, Shaanxi Province, China
Co-first authors: Lin He and Chan Zhu.
Author contributions: Shu MG designed and coordinated the study; He L and Zhu C performed the experiments, acquired and analyzed data, wrote the manuscript; Yu XY and Dou HC interpreted the data; all authors approved the final version of the article.
Supported by the Key Research and Development Plan of Shaanxi Province of China, No. 2023-YBSF-179; and Scientific Research Fund of The First Affiliated Hospital of Xi’an Jiaotong University, No. 2021ZYTS-35.
Institutional animal care and use committee statement: The study was approved by the Ethics Committee of Xi’an Jiaotong University School of Medicine (approval No. 2023-65).
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: No additional data are available.
Corresponding author: Mao-Guo Shu, MD, Doctor, Department of Plastic, Aesthetic and Maxillofacial Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 Yanta West Road, Xi’an 710061, Shaanxi Province, China. maoguoshu@xjtu.edu.cn
Received: September 15, 2025
Revised: November 12, 2025
Accepted: February 6, 2026
Published online: April 15, 2026
Processing time: 216 Days and 2.2 Hours
Revised: November 12, 2025
Accepted: February 6, 2026
Published online: April 15, 2026
Processing time: 216 Days and 2.2 Hours
Core Tip
Core Tip: High expression of C1q tumor necrosis factor associated protein 3 (CTRP3) promotes the wound healing of diabetic mice, and this may related to the protective effects on keratinocytes. The underlying mechanism is linked to the activation of phosphoinositide 3-kinase/protein kinase B pathway by reducing the PTEN protein level. Taken together, CTRP3 may be a novel target to accelerate the wound healing in diabetes.