Mitochondrial autophagy in diabetes-related cognitive decline and skin ulcers: Mechanistic insights and therapeutic implications

doi:10.4239/wjd.v17.i3.112177

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. Mar 15, 2026; 17(3): 112177
Published online Mar 15, 2026. doi: 10.4239/wjd.v17.i3.112177

Mitochondrial autophagy in diabetes-related cognitive decline and skin ulcers: Mechanistic insights and therapeutic implications

Xing Chen, Ling-Ling Zhang, Yu Zhou, Dong-Xiang Dong, Xiao-Ying Qian

Xing Chen, Ling-Ling Zhang, Yu Zhou, Dong-Xiang Dong, Xiao-Ying Qian, Department of Dermatology, Third Affiliated Hospital of Jiaxing University School of Medicine, Jiaxing 314000, Zhejiang Province, China

Author contributions: Chen X wrote the paper; Zhang LL, Zhou Y and Dong DX gathered the information; Qian XY directed the study. The final article was examined, edited, and approved by all the authors, who also agreed to take responsibility for all the elements of the work and make critical revisions for significant intellectual content.

Conflict-of-interest statement: The authors declare that they have no conflicts of interest related to this manuscript.

Corresponding author: Xiao-Ying Qian, Department of Dermatology, Third Affiliated Hospital of Jiaxing University School of Medicine, No. 309 Shuangyuan Road, Nanhu District, Jiaxing 314000, Zhejiang Province, China. 19957380102@163.com

Received: July 29, 2025
Revised: September 18, 2025
Accepted: January 12, 2026
Published online: March 15, 2026
Processing time: 226 Days and 1.5 Hours

Core Tip

Core Tip: The mechanism of mitochondrial autophagy in skin ulcers and cognitive decline associated with diabetes is the main topic of this review. This study aimed to clarify the crucial role of mitochondrial autophagy in maintaining the metabolic balance of cells, provide potential therapeutic strategies and intervention methods, and offer new concepts for the clinical management of diabetes-related complications. It also examined how mitochondrial autophagy reduces neurodegeneration brought on by diabetes and supports the molecular pathway of skin healing by removing damaged mitochondria.