Endothelial cell-derived exosomes inhibit high glucose-induced osteoblast ferroptosis by activating microRNA-335-3p/prostaglandin endoperoxide synthase 2

doi:10.4239/wjd.v17.i1.111165

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Diabetes. Jan 15, 2026; 17(1): 111165
Published online Jan 15, 2026. doi: 10.4239/wjd.v17.i1.111165

Endothelial cell-derived exosomes inhibit high glucose-induced osteoblast ferroptosis by activating microRNA-335-3p/prostaglandin endoperoxide synthase 2

Chen Shao, Li-Jian Zhang, Yi-Lin Song, Yan-Qiu Wang, Xiu-Jing Zha, Juan Li, Cheng-Song Ye, Ling-Ling Chen, Ming-Wei Chen, Guo-Xi Jin

Chen Shao, Ming-Wei Chen, Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China

Chen Shao, Yan-Qiu Wang, Xiu-Jing Zha, Juan Li, Cheng-Song Ye, Department of Endocrinology, The Second Affiliated Hospital of Bengbu Medical University, Bengbu 233000, Anhui Province, China

Li-Jian Zhang, Guo-Xi Jin, Department of Endocrinology, The First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, Anhui Province, China

Yi-Lin Song, Department of Nephrology, The Second Affiliated Hospital of Bengbu Medical University, Bengbu 233000, Anhui Province, China

Ling-Ling Chen, Department of Nursing, The Second Affiliated Hospital of Bengbu Medical University, Bengbu 233000, Anhui Province, China

Co-corresponding authors: Ming-Wei Chen and Guo-Xi Jin.

Author contributions: Shao C led the experimental design and implementation, responsible for data analysis and main writing and revision of the paper; Zhang LJ participated in the formulation and execution of the experimental plan, assisted in data organization and analysis; Song YL was responsible for the preparation of experimental materials and part of the data processing work; Wang YQ participated in experimental operations, and was responsible for recording and preliminary analysis of experimental data; Zha XJ assisted in experimental design and implementation, provided necessary technical support; Li J participated in data collection and organization, proofread the paper; Li J and Chen MW participated in the revision of the paper; Ye CS and Chen LL were responsible for the maintenance of experimental equipment and data collection; Chen MW provided suggestions for experimental design, participated in the discussion of the paper; Jin GX was responsible for overall project guidance and supervision, conducted the final review and approval of the paper; Chen MW and Jin GX made equal contributions as co-corresponding authors. All authors approved the final version to publish.

Supported by Natural Science Projects of Bengbu Medical College, No. 2022byzd088; Anhui Province Higher Education Scientific Research Project, No. 2024AH051285; Anhui Provincial Department of Education Humanities and Social Science Key Project, No. 2023AH051900; and the Key Research and Development Program Projects of Anhui Province, No. 202204295107020049.

Institutional review board statement: The study was reviewed and approved by the Medical Ethics Committee of Bengbu Medical University, No. [2023]269.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Data sharing statement: The data generated during and/or analyzed during the present study are available from the corresponding author upon reasonable request.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Guo-Xi Jin, PhD, Chief Physician, Professor, Department of Endocrinology, The First Affiliated Hospital of Bengbu Medical University, No. 287 Changhuai Road, Bengbu 233004, Anhui Province, China. jinguoxi@bbmu.edu.cn

Received: June 25, 2025
Revised: July 21, 2025
Accepted: December 2, 2025
Published online: January 15, 2026
Processing time: 204 Days and 2.3 Hours

Core Tip

Core Tip: Endothelial cell-derived exosomes demonstrate inherent bone-targeting properties, their role in counteracting high glucose-induced osteoblast ferroptosis remains unexplored. This study reveals that endothelial cell-derived exosomes protect osteoblasts from high glucose-induced ferroptosis by regulating microRNA-335-3p/prostaglandin endoperoxide synthase 2. The diagnostic potential of serum microRNA-335-3p for diabetic osteoporosis was demonstrated, warranting further validation with an expanded sample size.