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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Sep 15, 2025; 16(9): 107693
Published online Sep 15, 2025. doi: 10.4239/wjd.v16.i9.107693
Published online Sep 15, 2025. doi: 10.4239/wjd.v16.i9.107693
Current status and mechanistic insights into nontarget coronary lesions in patients with diabetes and early abnormal glucose metabolism
Shi-Qi Liu, Cheng-Chun Tang, School of Medicine, Southeast University, Nanjing 210009, Jiangsu Province, China
Shi-Qi Liu, Dong Wang, Cheng-Chun Tang, Department of Cardiology, Zhongda Hospital, Southeast University, Nanjing 210009, Jiangsu Province, China
Co-corresponding authors: Dong Wang and Cheng-Chun Tang.
Author contributions: Liu SQ, Wang D, and Tang CC conceived, designed, and refined this review; Liu SQ drafted the manuscript; Wang D and Tang CC contributed equally to this work as co-corresponding authors. All authors approved the final version to publish.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dong Wang, Department of Cardiology, Zhongda Hospital, Southeast University, No. 87 Dingjiaqiao, Gulou District, Nanjing 210009, Jiangsu Province, China.
Received: April 1, 2025
Revised: May 10, 2025
Accepted: July 30, 2025
Published online: September 15, 2025
Processing time: 166 Days and 8.9 Hours
Revised: May 10, 2025
Accepted: July 30, 2025
Published online: September 15, 2025
Processing time: 166 Days and 8.9 Hours
Core Tip
Core Tip: The number of nontarget-related recurrent cardiovascular events is increasing. Poor glycemic control, insulin use, and dyslipidemia contribute to high-risk plaque progression. Early glucose metabolism abnormalities and glycemic fluctuations further increase cardiovascular risk. This review examines the clinical and plaque characteristics of these patients with diabetes and early glucose metabolism abnormalities, percutaneous coronary intervention strategies for nontarget lesions, and the mechanistic roles of inflammation, hypercoagulability, oxidative stress, and endothelial dysfunction in adverse cardiovascular outcomes.