Published online Sep 15, 2025. doi: 10.4239/wjd.v16.i9.107517
Revised: May 20, 2025
Accepted: August 19, 2025
Published online: September 15, 2025
Processing time: 170 Days and 11.3 Hours
Core Tip: Recent research has led to a paradigm shift in the treatment approach for type 2 diabetes mellitus (T2DM). The “twin cycle hypothesis” and evidence supporting diabetes remission have shown that the condition results from excess fat accumulation above the personal fat threshold. When excess fat deposition leads to organ dysfunction, we term it as adiposity-induced metabolic dysfunction associated disease. T2DM is a part of the spectrum of diseases caused by excess fat accumulation. Hence, it is the need of the hour to update the terminology and we propose a new terminology for T2DM. The proposed terminology is more reflective of the multifaceted nature of the disease, reshapes the management protocols and helps in earlier diagnosis and treatment.
