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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Sep 15, 2025; 16(9): 106914
Published online Sep 15, 2025. doi: 10.4239/wjd.v16.i9.106914
Published online Sep 15, 2025. doi: 10.4239/wjd.v16.i9.106914
Albuminuria is independently associated with preclinical left ventricular systolic dysfunction: The TESEO study
Federica Barutta, Alessandro Andreis, Matteo Bellettini, Guglielmo Beccuti, Arianna Ferro, Martina Bollati, Stefania Bellini, Giulia Gioiello, Giulio Mengozzi, Gaetano M De Ferrari, Gianluca Alunni, Fabio Broglio, Gabriella Gruden, Department of Medical Sciences, University of Turin, Turin 10126, Italy
Alessandro Andreis, Gaetano M De Ferrari, Division of Cardiology, Città della Salute e della Scienza di Torino, Turin 10126, Italy
Alessandro Andreis, Gianluca Alunni, Advanced Cardiovascular Echocardiography Unit, Department of Cardiovascular and Thoracic, Città della Salute e della Scienza di Torino, University Hospital, Turin 10126, Italy
Co-first authors: Federica Barutta and Alessandro Andreis.
Author contributions: Barutta F and Andreis A analyzed the data and wrote the manuscript, they contributed equally to this article, they are the co-first authors of this manuscript; Bellettini M, Beccuti G, Ferro A, Bellettini M, Bellini S, and Gioiello G performed research; Mengozzi G, De Ferrari GM, Alunni G, and Broglio F reviewed and edited the manuscript; Gruden G designed and directed the study, wrote the manuscript, had access to all data, and is responsible for the integrity of the data and the accuracy of the data analysis; and all authors have read and approved the final manuscript.
Supported by the Italian Ministry for Education, University and Research under the Programme “Dipartimenti di Eccellenza 2018-2022” Project, No. D15D18000410001; and Novo Nordisk “Gestione delle complicanze croniche del diabete: From bedside to bench?”, No. n1/2021.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the City of Health and Science of Turin, approval No. D15D18000410001.
Clinical trial registration statement: The clinical trial statement is not applicable as this study is not a clinical trial.
Informed consent statement: All participants provided written informed consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Federica Barutta, Department of Medical Sciences, University of Turin, Corso Dogliotti 14, Turin 10126, Italy. federica.barutta@unito.it
Received: March 11, 2025
Revised: May 7, 2025
Accepted: August 4, 2025
Published online: September 15, 2025
Processing time: 185 Days and 0.4 Hours
Revised: May 7, 2025
Accepted: August 4, 2025
Published online: September 15, 2025
Processing time: 185 Days and 0.4 Hours
Core Tip
Core Tip: This study provides evidence that the prevalence of preclinical global longitudinal strain-left ventricular systolic dysfunction was elevated in type 2 diabetic patients despite the short duration of the disease and that albuminuria was independently as