Letter to the Editor
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jun 15, 2025; 16(6): 106884
Published online Jun 15, 2025. doi: 10.4239/wjd.v16.i6.106884
Immune biomarkers as early indicators of renal damage in type 1 diabetic children: A step toward translational medicine
Jian-Wen Fan, Su-Yi Xu, Jun Wu, Yong-Wei Yu
Jian-Wen Fan, Su-Yi Xu, Jun Wu, Department of Nursing, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Jian-Wen Fan, Su-Yi Xu, Jun Wu, Department of Outpatient Care, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Yong-Wei Yu, Department of Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Author contributions: Fan JW wrote the manuscript; Xu SY and Wu J collecting relevant references; Yu YW designed the study and revised the manuscript. All listed authors consent to the submission.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yong-Wei Yu, Department of Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Shangcheng District, Hangzhou 310003, Zhejiang Province, China. yuyongwei@zju.edu.cn
Received: March 10, 2025
Revised: April 4, 2025
Accepted: April 14, 2025
Published online: June 15, 2025
Processing time: 95 Days and 20.2 Hours
Core Tip

Core Tip: Immune biomarkers play a crucial role in the early detection of renal damage in children with type 1 diabetes. This letter highlights the need for integrating immune indicators into a dynamic risk stratification model, combining metabolic and genetic factors for improved predictive accuracy. Additionally, we emphasize the importance of longitudinal studies to assess biomarker temporal dynamics and explore immunomodulatory strategies for early intervention. Advancing these approaches could enhance the clinical utility of immune biomarkers, facilitating their translation into routine diagnostics and personalized treatment strategies for diabetic nephropathy prevention.