Retrospective Study
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World J Diabetes. Jun 15, 2025; 16(6): 104120
Published online Jun 15, 2025. doi: 10.4239/wjd.v16.i6.104120
Associations of nontraditional lipoprotein ratios with future cardiovascular events in patients with type 2 diabetes mellitus
Si-Min Deng, Xin-Qun Hu, Xiang-Yu Zhang
Si-Min Deng, Xiang-Yu Zhang, Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
Xin-Qun Hu, Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
Author contributions: Zhang XY designed the research study; Deng SM performed the research and wrote the manuscript; Hu XQ analyzed the data; and all authors have read and approve the final manuscript.
Institutional review board statement: The study was exempt from ethical review and approval, as no additional institutional review board approval was necessary for the secondary analysis.
Informed consent statement: The data for our study are derived from the Action to Control Cardiovascular Risk in Diabetes. All participants completed informed consent forms before participating in the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The original data are available from the NHLBI BioLINCC. Some or all of the data sets generated and/or analyzed in the current study are not publicly available, but may be obtained from the corresponding author upon reasonable request at xiangyuzhang@csu.edu.cn.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiang-Yu Zhang, PhD, Professor, Department of Geriatrics, The Second Xiangya Hospital, Central South University, No. 139 Renmin Middle Road, Changsha 410011, Hunan Province, China. xiangyuzhang@csu.edu.cn
Received: December 11, 2024
Revised: March 30, 2025
Accepted: May 15, 2025
Published online: June 15, 2025
Processing time: 185 Days and 4.5 Hours
Core Tip

Core Tip: This research demonstrates that elevated nontraditional lipoprotein ratios may independently predict the risk of major adverse cardiovascular events and congestive heart failure in patients with type 2 diabetes mellitus. Our findings provide evidence supporting the use of nontraditional lipoprotein ratios as reliable bioindicators of cardiovascular event risk in patients with type 2 diabetes mellitus.