Neurophysiological mechanisms of electroacupuncture in regulating pancreatic function and adipose tissue expansion

doi:10.4239/wjd.v16.i5.101354

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May 15, 2025 (publication date) through Apr 25, 2025

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. May 15, 2025; 16(5): 101354
Published online May 15, 2025. doi: 10.4239/wjd.v16.i5.101354

Neurophysiological mechanisms of electroacupuncture in regulating pancreatic function and adipose tissue expansion

Yun Liu, Zhi Yu, Xuan Wang, Ming-Qian Yuan, Meng-Jiang Lu, Mei-Rong Gong, Qian Li, You-Bing Xia, Guan-Hu Yang, Bin Xu, Gerhard Litscher, Tian-Cheng Xu

Yun Liu, Zhi Yu, Ming-Qian Yuan, Meng-Jiang Lu, Mei-Rong Gong, Qian Li, Bin Xu, Tian-Cheng Xu, Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China

Xuan Wang, College of Traditional Chinese Medicine, Jiangsu Vocational College of Medicine, Yancheng 224000, Jiangsu Province, China

You-Bing Xia, Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, Xuzhou 221004, Jiangsu Province, China

Guan-Hu Yang, Department of Specialty Medicine, Ohio University, Athens, OH 45701, United States

Gerhard Litscher, High-Tech Acupuncture and Digital Chinese Medicine, Swiss University of Traditional Chinese Medicine, Bad Zurzach 5530, Switzerland

Co-first authors: Yun Liu and Zhi Yu.

Co-corresponding authors: Bin Xu and Tian-Cheng Xu.

Author contributions: Liu Y and Yu Z contributed equally to this study as co-first authors; Xu B and Xu TC contributed equally to this study as co-corresponding authors; Liu Y, Wang X and Yu Z conceived and designed the experiments; Liu Y, Yuan MQ, Li Q and Lu MJ performed the experiments, wrote the manuscript; Yang GH and Litscher G analyzed the data; Liu Y, Gong MR and Xia YB performed the experiments; Xu B and Xu TC provided guidance and funding support.

Supported by National Natural Science Foundation of China, No. 82305376, No. 82374577, No. 82305375, No. 82074532, and No. 82405567; and The Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).

Institutional animal care and use committee statement: The study was reviewed and approved by the Model Animal Research Center at Nanjing University of Chinese Medicine Institutional Review Board (Approval No. 202105A041).

Conflict-of-interest statement: There is no actual or potential conflict of interest in relation to this article.

ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.

Data sharing statement: No additional data are available.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Tian-Cheng Xu, PhD, Professor, Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Office 627, Fengsheng Health Building, Nanjing 210023, Jiangsu Province, China. xtc@njucm.edu.cn

Received: September 12, 2024
Revised: February 12, 2025
Accepted: March 14, 2025
Published online: May 15, 2025
Processing time: 225 Days and 16.3 Hours

Core Tip

Core Tip: This study underscored the pivotal role of peripancreatic adipose tissue expansion in the transition from obesity to type 2 diabetes mellitus (T2DM), influenced by the crosstalk between islet beta cells and the pancreas islet nerve system. Our findings revealed that electroacupuncture (EA), particularly when applied at ST25, effectively regulates glucolipid metabolism and pancreatic function via the TRPV1-CGRP signaling axis, thereby mitigating metabolic stress and inflammation. This provides a foundation for the development of precision therapeutic strategies for T2DM management. Ongoing exploration of the detailed mechanisms and therapeutic targets of EA at various acupoints, including LI11 and ST37, is essential for refining clinical methodologies aimed at T2DM treatment.