Observational Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Mar 15, 2025; 16(3): 99108
Published online Mar 15, 2025. doi: 10.4239/wjd.v16.i3.99108
Association between high-sensitivity troponin T levels below the ninety-ninth percentile and diabetic kidney disease: A cross-sectional study
Xiao-Yan Luo, Li-Hua Huang, Kun-Peng Kang
Xiao-Yan Luo, Department of Interventional Radiology, The Second Affiliated Hospital of Gannan Medical University, Ganzhou 341600, Jiangxi Province, China
Li-Hua Huang, Department of Clinical Laboratory, The Second Affiliated Hospital of Gannan Medical University, Ganzhou 341600, Jiangxi Province, China
Kun-Peng Kang, Department of Cardiovascular Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
Co-first authors: Xiao-Yan Luo and Li-Hua Huang.
Author contributions: Luo XY and Huang LH designed the study, developed the methodology, and participated in formal analysis and investigation, and they contributed equally to this article as co-first authors; Luo XY drafted the original manuscript; Huang LH and Kang KP contributed to the review and editing process; and all authors have read and approved the final manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the Second Affiliated Hospital of Gannan Medical University (approval No. EFYJ20240113007).
Informed consent statement: Both the National Health and Nutrition Examination Survey protocol and the measurement of high-sensitivity troponin T in stored samples were approved by the Ethics Review Board of the National Center for Health Statistics. Written informed consent was obtained from all participants.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: Publicly accessible datasets pertinent to this study are accessible online. The nomenclature of the repository/repositories can be found at the following web address: http: //www.cdc.gov/nchs/nhanes.htm.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kun-Peng Kang, MD, Department of Cardiovascular Medicine, The First Affiliated Hospital of Gannan Medical University, No. 128 Jinling West Road, Ganzhou Economic and Technological Development Zone, Ganzhou 341000, Jiangxi Province, China. gydkangkunpeng@163.com
Received: July 14, 2024
Revised: December 13, 2024
Accepted: January 6, 2025
Published online: March 15, 2025
Processing time: 191 Days and 5.8 Hours
Core Tip

Core Tip: High-sensitivity troponin T levels below the 99th percentile show a significant linear association with diabetic kidney disease in type 2 diabetes mellitus patients. This association, derived from National Health and Nutrition Examination Survey data analysis, suggests that even subclinical elevations in high-sensitivity troponin T could serve as an early indicator for diabetic kidney disease risk assessment, particularly in the highest tertile (9.80-21.88 ng/L) with an odds ratio of 2.07.