Premixed insulin: Advantages, disadvantages, and future

Core Tip

Core Tip: Premixed insulin improved patient adherence because of its simplified treatment regimens, fewer injections, and low price. Therefore, premixed insulin is widely used, especially in developed countries. However, patients receiving premixed insulin commonly have less satisfactory blood glucose control. The fixed ratio of premixed insulin usually fails to meet the nuanced demands of individualized glucose-lowering therapy. Moreover, aberrant local absorption and potential systemic autoimmune responses of premixed insulin may further affect glycemic control. New insulin formulations offer improved blood glucose control, weight management, and reduced hypoglycemia. Further studies are needed to guide the optimization of insulin use through individualized treatment approaches or to mitigate the side effects of premixed insulin through novel drug combinations.