Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Mar 15, 2025; 16(3): 102277
Published online Mar 15, 2025. doi: 10.4239/wjd.v16.i3.102277
Role of duodenal mucosal resurfacing in controlling diabetes in rats
Li-Juan Nie, Zhe Cheng, Yi-Xian He, Qian-Hua Yan, Yao-Huan Sun, Xin-Yi Yang, Jie Tian, Peng-Fei Zhu, Jiang-Yi Yu, Hui-Ping Zhou, Xi-Qiao Zhou
Li-Juan Nie, Zhe Cheng, Yi-Xian He, Qian-Hua Yan, Yao-Huan Sun, Xin-Yi Yang, Jie Tian, Peng-Fei Zhu, Jiang-Yi Yu, Xi-Qiao Zhou, Department of Endocrinology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, Jiangsu Province, China
Li-Juan Nie, School of Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China
Hui-Ping Zhou, Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23284, United States
Co-first authors: Li-Juan Nie and Zhe Cheng.
Author contributions: Zhou XQ and Nie LJ conceived the idea and designed the study; Nie LJ, Cheng Z, He YX and Zhou XQ wrote the study protocol; Yan QH, Sun YH, Yang XY, Zhu PF, Tian J, Yu JY, and Zhou HP participated in the discussion and modification of the experimental plan; Nie LJ, Cheng Z and He YX performed the research and data analyses; Nie LJ wrote the manuscript; Zhou HP and Zhou XQ revised the manuscript; All authors had approved the final manuscript for submission.
Supported by the National Natural Science Foundation of China, No. 82474318; the Jiangsu Administration of Traditional Chinese Medicine, No. zt202105; Subject of Jiangsu Province Hospital of Chinese Medicine, No. Y2021rc22; and a Research Career Scientist Award (to Zhou HP) from the Department of Veterans Affairs (United States), No. 2IK6BX004477-06.
Institutional review board statement: The study does not involve any human experiments.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Jiangsu Center for Safety Evaluation of Drugs (No. IACUC-20220613-01).
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: Detailed methods and datasets supporting the findings of the present study are available from the corresponding author upon request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xi-Qiao Zhou, PhD, Professor, Department of Endocrinology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, No. 155 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. zhouxiqiao@njucm.edu.cn
Received: October 15, 2024
Revised: December 9, 2024
Accepted: January 3, 2025
Published online: March 15, 2025
Processing time: 98 Days and 3.2 Hours
Core Tip

Core Tip: Duodenum is a particular metabolic signaling center, and the thickened mucous membranes cause duodenal dysfunction and promote insulin resistance. This study explored the mechanisms by which duodenal mucosal resurfacing (DMR) affects type 2 diabetes (T2D) using a rat model. It highlights the potential role of the Blautia genus in the pathogenesis of T2D and the therapeutic effect of DMR. The results provide a theoretical basis for performing DMR in humans with T2D and identify several areas requiring further research.