Systematic Reviews
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Feb 15, 2025; 16(2): 99200
Published online Feb 15, 2025. doi: 10.4239/wjd.v16.i2.99200
DNA methylation in the association between pesticide exposures and type 2 diabetes
Guang-Jun Zheng, Zheng-Er Fang, Bi-Ying Zhou, Lei Zuo, Xia Chen, Ming-Liang Liu, Lei Yu, Chun-Xia Jing, Guang Hao
Guang-Jun Zheng, Zheng-Er Fang, Bi-Ying Zhou, Lei Zuo, Xia Chen, Ming-Liang Liu, Chun-Xia Jing, Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou 510632, Guangdong Province, China
Lei Yu, Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong Province, China
Chun-Xia Jing, Guangdong Key Laboratory of Environmental Exposure and Health, Jinan University, Guangzhou 510632, Guangdong Province, China
Guang Hao, Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510632, Guangdong Province, China
Co-first authors: Guang-Jun Zheng and Zheng-Er Fang.
Author contributions: Zheng GJ and Fang ZE should be considered as joint first authors because they contributed equally to this study; All authors contributed to the study conception and design; Hao G and Jing CX were responsible for conceptualization, methodology, supervision, and editing sections; Zheng GJ and Fang ZE tasked with the literature search, data collection, investigation, visualization, and original draft writing sections; Zhou BY, Zuo L, Chen X, Liu ML and Yu L reviewed the article and made helpful suggestions; All authors read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guang Hao, MD, PhD, Associate Professor, Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, School of Public Health, Guangdong Pharmaceutical University, No. 283 Jianghai Avenue, Guangzhou 510632, Guangdong Province, China. haoguang2015@hotmail.com
Received: July 16, 2024
Revised: September 30, 2024
Accepted: November 21, 2024
Published online: February 15, 2025
Processing time: 166 Days and 22.1 Hours
Core Tip

Core Tip: Previous studies have reported an association between pesticide exposure and the incidence of type 2 diabetes (T2D), but the underlying mechanisms have not been fully elucidated. In this article, we speculated that DNA methylation may be associated with pesticide exposure and T2D. We systematically reviewed the current literature to identify genes that are not only associated with pesticide exposure but also with T2D. Six genes (Alu, CABLES1, CDH1, PDX1, PTEN, PTPRN2) were identified.