Meta-Analysis
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Feb 15, 2025; 16(2): 97077
Published online Feb 15, 2025. doi: 10.4239/wjd.v16.i2.97077
Evaluating the effectiveness of ultrasound-assisted wound debridement in managing diabetic foot ulcers: A systematic review and meta-analysis
Rui Yang, Geng Chen, Qing-Yun Pan, Yao Yao, Yan-Fen Li, Hai-Ting Chen, Chang-Jiang Lei, Xia Liang
Rui Yang, Department of Thoracic and Cardiovascular Surgery, The Second Affiliated Hospital of Jianghan University (The Fifth Hospital of Wuhan), Wuhan 430050, Hubei Province, China
Geng Chen, Jianghan University, Wuhan 430050, Hubei Province, China
Qing-Yun Pan, Yao Yao, Department of Endocrinology, The Fifth Hospital of Wuhan, Wuhan 430050, Hubei Province, China
Yan-Fen Li, Department of Anorectal Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, Guangdong Province, China
Hai-Ting Chen, Department of Emergency Medical Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, Guangdong Province, China
Chang-Jiang Lei, Department of Oncology, The Second Affiliated Hospital of Jianghan University (The Fifth Hospital of Wuhan), Wuhan 430050, Hubei Province, China
Xia Liang, Department of Nursing, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, Guangdong Province, China
Co-first authors: Rui Yang and Geng Chen.
Co-corresponding authors: Chang-Jiang Lei and Xia Liang.
Author contributions: Yang R and Chen G designed the research; Pan QY and Yao Y performed the research and contributed to the methodology; Yang R, Chen G, and Li YF contributed new reagents or analytic tools; Pan QY, Yao Y, and Chen HT analyzed the data; Yang R, Chen G, Pan QY, and Yao Y wrote the paper. Yang R and Chen G equally contributed to this work as co-first authors. Lei CJ and Liang X equally contributed to the study's design, data analysis, and manuscript preparation, and reviewed and edited the manuscript. Lei CJ and Liang X have closely collaborated on this research project, equally contributing in guiding the study design, data analysis, and manuscript preparation.
Supported by Hubei Province Top Medical Youth Talent Program, Wuhan Knowledge Innovation Special Basic Research Project, No. 2023020201020558; Clinical Research Project of Affiliated Hospital of Guangdong Medical University, No. LCYJ2021B004 and No. LCYJ2019B010; and Science and Technology Plan Project of Zhanjiang, No. 2022A01191.
Conflict-of-interest statement: The authors declare that they have no competing interests.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chang-Jiang Lei, MD, Doctor, Department of Oncology, The Second Affiliated Hospital of Jianghan University (The Fifth Hospital of Wuhan), No. 122 Xianzheng Street, Hanyang District, Wuhan 430050, Hubei Province, China. leichangj0420@163.com
Received: May 22, 2024
Revised: October 2, 2024
Accepted: October 30, 2024
Published online: February 15, 2025
Processing time: 222 Days and 5.9 Hours
Core Tip

Core Tip: Ultrasound-assisted wound debridement (UAWD) significantly accelerates the healing process of diabetic foot ulcers (DFUs) compared to standard treatment methods. Our meta-analysis of randomized controlled trials reveals a notable enhancement in DFU healing rates with the application of UAWD. Evidence from the study supports the integration of UAWD into standard DFU care protocols to improve patient outcomes. Sensitivity analysis and rigorous assessment for publication bias confirm the robustness and reliability of our findings regarding the efficacy of UAWD. The adoption of UAWD could represent a pivotal shift in DFU management, offering a more effective solution for a widespread clinical challenge.