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Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Dec 15, 2025; 16(12): 110028
Published online Dec 15, 2025. doi: 10.4239/wjd.v16.i12.110028
Long-term and short-term exposure to outdoor air pollution and its association with glycolipid metabolic disorders
Chang Zhou, Gao-Yuan Cui, Yi-Hu Tang, Wu-Yang Zhang, Xue-Lun Zou
Chang Zhou, Department of Oncology, The Third Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, China
Gao-Yuan Cui, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
Yi-Hu Tang, Department of Emergency, The Third Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, China
Wu-Yang Zhang, Clinical Skills Training Center, Central South University, Changsha 410008, Hunan Province, China
Xue-Lun Zou, Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
Author contributions: Zou XL and Zhou C designed the research and determined the structure of the manuscript. Zou XL, Tang YS, Cui GY, and Zhou C were involved in the implementation of this study. Zou XL, Cui GY, and Zhou C selected the references and contributed to the writing. Zou XL, Tang YS, and Zhou C contributed to the revision and finalization of the manuscript. The manuscript was polished by Zhang WY. All authors contributed to the article and approved the submitted version.
Supported by the Teaching Research and Reform Fund Project of Central South University, No. 2024jy178.
Institutional review board statement: There was no need to get informed consent or ethical approval for this study again because all of the data were taken from published sources, and the informed consent and approval were received.
Informed consent statement: There was no need to get informed consent or ethical approval for this study again because all of the data were taken from published sources, and the informed consent and approval were received.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: The original contributions presented in the study are included in the manuscript. Further inquiries can be directed to the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xue-Lun Zou, PhD, Department of Neurology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha 410008, Hunan Province, China. 1609941099@qq.com
Received: May 28, 2025
Revised: July 25, 2025
Accepted: November 13, 2025
Published online: December 15, 2025
Processing time: 201 Days and 11.8 Hours
Core Tip

Core Tip: This national cohort study shows that outdoor air pollution - particularly PM1, PM2.5, and their chemical components - is an important environmental factor contributing to glycolipid metabolic disorders, with long-term exposure showing greater metabolic toxicity than short-term exposure. The lack of association between indoor solid fuel pollutants and glycolipid metabolic disorders underscores the urgent need for targeted interventions to improve outdoor air quality and reduce metabolic risks at the population level.