Pan ZL, Li MQ, Zhang J, Xue LY, Shi YP. Correlation of gut microbiota metabolite trimethylamine N-oxide with inflammatory levels and osteoporosis in patients with diabetic nephropathy. World J Diabetes 2025; 16(11): 109919 [DOI: 10.4239/wjd.v16.i11.109919]
Corresponding Author of This Article
Yan-Ping Shi, Department of Nephrology, The Second Affiliated Hospital of Shandong First Medical University, No. 366 Taishan Avenue, Tai’an 271000, Shandong Province, China. shiyanping1823@126.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Nov 15, 2025 (publication date) through Nov 14, 2025
Times Cited of This Article
Times Cited (0)
Journal Information of This Article
Publication Name
World Journal of Diabetes
ISSN
1948-9358
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Pan ZL, Li MQ, Zhang J, Xue LY, Shi YP. Correlation of gut microbiota metabolite trimethylamine N-oxide with inflammatory levels and osteoporosis in patients with diabetic nephropathy. World J Diabetes 2025; 16(11): 109919 [DOI: 10.4239/wjd.v16.i11.109919]
World J Diabetes. Nov 15, 2025; 16(11): 109919 Published online Nov 15, 2025. doi: 10.4239/wjd.v16.i11.109919
Correlation of gut microbiota metabolite trimethylamine N-oxide with inflammatory levels and osteoporosis in patients with diabetic nephropathy
Zhang-Lei Pan, Ming-Qiang Li, Jing Zhang, Ling-Yu Xue, Yan-Ping Shi
Zhang-Lei Pan, Jing Zhang, Ling-Yu Xue, Yan-Ping Shi, Department of Nephrology, The Second Affiliated Hospital of Shandong First Medical University, Tai’an 271000, Shandong Province, China
Ming-Qiang Li, Department of Urology, Tai’an Central Hospital Affiliated to Qingdao University, Tai’an 271000, Shandong Province, China
Author contributions: Pan ZL and Li MQ were the guarantors and designed the study; Pan ZL, Zhang J, and Xue LY participated in the acquisition, analysis, and interpretation of the data, and drafted the initial manuscript; Pan ZL and Shi YP revised the article critically for important intellectual content.
Institutional review board statement: The study was reviewed and approved by the Second Affiliated Hospital of Shandong First Medical University.
Informed consent statement: All study participants, or their legal guardians, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to declare.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Ping Shi, Department of Nephrology, The Second Affiliated Hospital of Shandong First Medical University, No. 366 Taishan Avenue, Tai’an 271000, Shandong Province, China. shiyanping1823@126.com
Received: June 17, 2025 Revised: July 31, 2025 Accepted: September 29, 2025 Published online: November 15, 2025 Processing time: 149 Days and 18.3 Hours
Core Tip
Core Tip: In recent years, with in-depth research on the gut microbiota and the emergence of concepts such as the "gut-kidney axis" and the "intestinal-bone axis", the key role of the gut microbiota and its metabolites in metabolic disorders, inflammatory responses, and target organ damage has been increasingly recognized. Trimethylamine N-oxide (TMAO) is the main metabolite produced by the gut microbiota from dietary nutrients such as phosphatidylcholine and choline, and has attracted attention due to its participation in the pathogenesis of diabetic nephropathy (DN). In this study, we aim to explore the correlation between TMAO levels and the levels of inflammatory markers and osteoporosis (OP) in patients with DN, providing a theoretical and practical basis for the early identification of high-risk patients and timely clinical intervention. The research results confirm that elevated TMAO levels may mediate the inflammatory response and bone metabolism disorder in patients with DN, thereby promoting the progression of systemic inflammation and OP.
