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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Oct 15, 2025; 16(10): 110722
Published online Oct 15, 2025. doi: 10.4239/wjd.v16.i10.110722
Published online Oct 15, 2025. doi: 10.4239/wjd.v16.i10.110722
Blood glucose variability impacts heart rate dynamics in older type 2 diabetic and coronary heart disease patients
An-Qi Li, Department of Metabolism and Endocrinology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421000, Hunan Province, China
Feng Zhang, Department of Neurosurgery, Hengyang Central Hospital, Hengyang 421000, Hunan Province, China
Author contributions: Li AQ wrote the paper, designed the research and analyzed the data; Li AQ and Zhang F performed the research; all authors made substantial intellectual contributions to this paper.
Supported by National Natural Science Foundation of China, No. 82270939; The Clinical Research 4310 Program of the First Affiliated Hospital of the University of South China, No. 20214310NHYCG02.
Institutional review board statement: This study was approved by the Ethic Committee of The First Affiliated Hospital, Hengyang Medical School, University of South China.
Informed consent statement: All the study subjects provided informed consent.
Conflict-of-interest statement: All the authors have no conflict of interest related to the manuscript.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Feng Zhang, Department of Neurosurgery, Hengyang Central Hospital, No. 12 Yancheng Road, Hengyang 421000, Hunan Province, China.
Received: June 27, 2025
Revised: August 1, 2025
Accepted: September 16, 2025
Published online: October 15, 2025
Processing time: 110 Days and 1.4 Hours
Revised: August 1, 2025
Accepted: September 16, 2025
Published online: October 15, 2025
Processing time: 110 Days and 1.4 Hours
Core Tip
Core Tip: Recent evidence has linked cardio-cerebrovascular events in type 2 diabetes mellitus patients with concurrent coronary artery disease to blood glucose (BG) fluctuation, and the greater the BG fluctuation, the higher the incidence of chronic vascular complications of diabetes mellitus and acute cardiovascular events, and the worse the prognosis. This study analyzes how BG variability impacts heart rate dynamics in such patients and the predictive properties of functional myocardial ischemia.