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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Oct 15, 2025; 16(10): 109763
Published online Oct 15, 2025. doi: 10.4239/wjd.v16.i10.109763
Published online Oct 15, 2025. doi: 10.4239/wjd.v16.i10.109763
Exosomes from adipose-derived stem cells: A potential therapeutic strategy for diabetic foot ulcers
Jia-Xin Mao, Si Chen, Jia-Cheng Li, Mu-Xin Zhao, Department of Plastic and Reconstructive Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian 116000, Liaoning Province, China
Han Wang, Department of Vascular Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian 116000, Liaoning Province, China
Author contributions: Mao JX was responsible for data organization and manuscript drafting; Zhao MX undertook the manuscript editing and correction process; Chen S contributed to the revision of figures in the manuscript; Li JC, Wang H and Zhao MX were involved in establishing the conceptual framework and overall structure of the manuscript; All authors have read and approve the final manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mu-Xin Zhao, PhD, Chief Physician, Department of Plastic and Reconstructive Surgery, The Second Affiliated Hospital of Dalian Medical University, No. 467 Zhongshan Road, Shahekou District, Dalian 116000, Liaoning Province, China.
Received: May 21, 2025
Revised: July 7, 2025
Accepted: August 28, 2025
Published online: October 15, 2025
Processing time: 147 Days and 19 Hours
Revised: July 7, 2025
Accepted: August 28, 2025
Published online: October 15, 2025
Processing time: 147 Days and 19 Hours
Core Tip
Core Tip: This review critically analyzes the current state of research on the efficacy of exosomes from adipose-derived stem cells in promoting the healing of diabetic foot ulcers. It offers a comprehensive overview of the risk factors and refractory mechanisms of diabetic foot ulcers and explores the mechanism and application of exosomes derived from adipose stem cells to promote wound healing in patients with diabetes mellitus. This review aimed to provide scientific evidence to support the clinical application of exosomes from adipose-derived stem cells for the treatment of diabetic foot ulcers.