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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Oct 15, 2025; 16(10): 109526
Published online Oct 15, 2025. doi: 10.4239/wjd.v16.i10.109526
Published online Oct 15, 2025. doi: 10.4239/wjd.v16.i10.109526
Right ventricular dysfunctions in type 1 diabetic mice: A longitudinal study
Jian-Jian Yu, Yi Tan, Jian-Xiang Xu, Lu Cai, Pediatric Research Institute, Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY 40202, United States
Jian-Jian Yu, Jian-Ge Han, Department of Anesthesiology, Tianjin University Chest Hospital, Tianjin 061102, China
Jian-Ge Han, Tianjin Key Laboratory of Cardiovascular Emergency and Critical Care, Tianjin Municipal Science and Technology Bureau, Tianjin 061102, China
Yi Tan, Jiapeng Huang, Lu Cai, Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, United States
Amanda LeBlanc, Cardiovascular and Thoracic Surgery, and Physiology, Cardiovascular Innovation Institute, University of Louisville School of Medicine, Louisville, KY 40202, United States
Amanda LeBlanc, Jiapeng Huang, Lu Cai, Center for Integrative Environmental Health Sciences, University of Louisville School of Medicine, Louisville, KY 40202, United States
Bradley B Keller, Cincinnati Children’s Heart Institute and Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229, United States
Jiapeng Huang, Departments of Anesthesiology and Perioperative Medicine, University of Louisville School of Medicine, Louisville, KY 40202, United States
Jiapeng Huang, Cardiovascular and Thoracic Surgery, and Medicine, Cardiovascular Innovation Institute, University of Louisville School of Medicine, Louisville, KY 40202, United States
Lu Cai, Department of Radiation Oncology, University of Louisville School of Medicine, Louisville, KY 40202, United States
Co-corresponding authors: Jiapeng Huang and Lu Cai.
Author contributions: Yu JJ and Xun JX performed experiments, interpreted data, and prepared the manuscript; Han JG, Tan Y, LeBlanc A, Keller BB, Huang J, and Cai L reviewed experimental progression, interpreted experimental data, reviewed and edited manuscripts; Huang J and Cai L designed and oversaw experiments; and they contributed equally to this manuscript and are co-corresponding authors. All authors reviewed and approved the final version.
Supported by the University of Louisville - China Pediatric Research Exchange Program (Cai L, Tan Y, Huang J, and Keller B, no salary support); University of Louisville Executive Vice President for Research and Innovation Internal Grant (Huang J and Cai L); and University of Louisville School of Medicine Basic Grant (Huang J and Cai L).
Institutional animal care and use committee statement: This study was approved by the Institutional Animal Care and Use Committee of University of Louisville (Approval No. IACUC 24365).
Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: Once published, we will share these important results with any readers upon request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lu Cai, MD, PhD, Professor, Pediatric Research Institute, Department of Pediatrics, University of Louisville School of Medicine, 570 South Preston Street, Baxter I, Louisville, KY 40202, United States. lu.cai@louisville.edu
Received: May 14, 2025
Revised: June 19, 2025
Accepted: September 10, 2025
Published online: October 15, 2025
Processing time: 154 Days and 16.9 Hours
Revised: June 19, 2025
Accepted: September 10, 2025
Published online: October 15, 2025
Processing time: 154 Days and 16.9 Hours
Core Tip
Core Tip: Diabetic cardiomyopathy is a diabetes-associated complication. However, the temporal relationship between right ventricle (RV) and left