Exploring the genetic basis of childhood monogenic diabetes

doi:10.4239/wjd.v15.i9.1829

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Sep 15, 2024 (publication date) through Nov 5, 2024

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Sep 15, 2024; 15(9): 1829-1832
Published online Sep 15, 2024. doi: 10.4239/wjd.v15.i9.1829

Exploring the genetic basis of childhood monogenic diabetes

Debmalya Sanyal

Debmalya Sanyal, Department of Endocrinology, KPC Medical College, Kolkata Pin 700032, West Bengal, India

Debmalya Sanyal, Department of Endocrinology, NH RTIICS, Kolkata Pin 700099, West Bengal, India

Debmalya Sanyal, School of Medicine, University of New Castle, Callaghan NSW 2308, Australia

Author contributions: Sanyal D contributed to manuscript development.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/

Corresponding author: Debmalya Sanyal, FACE, FRCP, MBBS, MD, MRCP, Professor, Department of Endocrinology, KPC Medical College, 1F Raja Subodh Chandra Mullick Road, Kolkata Pin 700032, West Bengal, India. drdebmalyasanyal@gmail.com

Received: December 18, 2023
Revised: May 29, 2024
Accepted: June 28, 2024
Published online: September 15, 2024
Processing time: 253 Days and 5.1 Hours

Core Tip

Core Tip: Monogenic diabetes, a rare yet impactful condition in childhood, results from genetic variations, causing early-onset diabetes. Affecting 1%-5% of children, early detection and tailored genetic treatments can enhance long-term health. Culprits include genetic variations in beta-cell regulatory genes and severe insulin resistance. Identifying specific types allows transitioning to sulfonylureas while maintaining glucose control. Tools to differentiate diabetes types underscore genetic screening's importance for prognosis and treatment guidance. This review delves into genetic insights into childhood monogenic diabetes, offering diagnosis and management guidance for affected youth's better health.