Age-specific heterogeneity of genetic susceptibility to cardiovascular disease might have opposite outcomes depending on the presence of prediabetes

doi:10.4239/wjd.v15.i6.1381

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Jun 15, 2024 (publication date) through Nov 3, 2024

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Diabetes. Jun 15, 2024; 15(6): 1381-1383
Published online Jun 15, 2024. doi: 10.4239/wjd.v15.i6.1381

Age-specific heterogeneity of genetic susceptibility to cardiovascular disease might have opposite outcomes depending on the presence of prediabetes

Chaeyoung Lee

Chaeyoung Lee, Department of Bioinformatics and Life Science, Soongsil University, Seoul 06978, South Korea

Author contributions: Lee C conceived ideas and constructs and wrote this article as the sole author.

Supported by National Research Foundation of Korea, No. 2018R1A2B6004867.

Conflict-of-interest statement: The author declares that there is no conflict of interest regarding the publication of this article.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Chaeyoung Lee, PhD, Professor, Department of Bioinformatics and Life Science, Soongsil University, 369 Sangdo-ro, Dongjak-gu, Seoul 06978, South Korea. clee@ssu.ac.kr

Received: February 27, 2024
Revised: April 21, 2024
Accepted: April 29, 2024
Published online: June 15, 2024
Processing time: 105 Days and 5 Hours

Core Tip

Core Tip: When prediabetes is present, younger individuals may demonstrate a heightened genetic susceptibility to cardiovascular disease (CVD) compared to their older counterparts. Conversely, in the absence of prediabetes, older individuals might harbor a greater genetic predisposition to CVD than their younger counterparts. This hypothetical scenario warrants confirmation through future studies, addressing specific issues highlighted in this article.