Lee C. Age-specific heterogeneity of genetic susceptibility to cardiovascular disease might have opposite outcomes depending on the presence of prediabetes. World J Diabetes 2024; 15(6): 1381-1383 [PMID: 38983829 DOI: 10.4239/wjd.v15.i6.1381]
Corresponding Author of This Article
Chaeyoung Lee, PhD, Professor, Department of Bioinformatics and Life Science, Soongsil University, 369 Sangdo-ro, Dongjak-gu, Seoul 06978, South Korea. clee@ssu.ac.kr
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Jun 15, 2024; 15(6): 1381-1383 Published online Jun 15, 2024. doi: 10.4239/wjd.v15.i6.1381
Age-specific heterogeneity of genetic susceptibility to cardiovascular disease might have opposite outcomes depending on the presence of prediabetes
Chaeyoung Lee
Chaeyoung Lee, Department of Bioinformatics and Life Science, Soongsil University, Seoul 06978, South Korea
Author contributions: Lee C conceived ideas and constructs and wrote this article as the sole author.
Supported byNational Research Foundation of Korea, No. 2018R1A2B6004867.
Conflict-of-interest statement: The author declares that there is no conflict of interest regarding the publication of this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chaeyoung Lee, PhD, Professor, Department of Bioinformatics and Life Science, Soongsil University, 369 Sangdo-ro, Dongjak-gu, Seoul 06978, South Korea. clee@ssu.ac.kr
Received: February 27, 2024 Revised: April 21, 2024 Accepted: April 29, 2024 Published online: June 15, 2024 Processing time: 105 Days and 5 Hours
Abstract
Examining age-specific heterogeneity of susceptibility to cardiovascular disease is also essential in individuals without prediabetes to determine its relative size and direction compared to those with prediabetes. Of particular interest, age-specific heterogeneity in genetic susceptibility may exhibit opposite directions depending on the presence or absence of prediabetes.
Core Tip: When prediabetes is present, younger individuals may demonstrate a heightened genetic susceptibility to cardiovascular disease (CVD) compared to their older counterparts. Conversely, in the absence of prediabetes, older individuals might harbor a greater genetic predisposition to CVD than their younger counterparts. This hypothetical scenario warrants confirmation through future studies, addressing specific issues highlighted in this article.
