Review
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jun 15, 2024; 15(6): 1142-1161
Published online Jun 15, 2024. doi: 10.4239/wjd.v15.i6.1142
Alternative therapeutic strategies in diabetes management
Alessia Annicchiarico, Barbara Barile, Cinzia Buccoliero, Grazia Paola Nicchia, Giacomina Brunetti
Alessia Annicchiarico, Barbara Barile, Cinzia Buccoliero, Grazia Paola Nicchia, Giacomina Brunetti, Department of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, Bari 70125, Italy
Author contributions: Annicchiarico A wrote the introduction and mesenchymal stem cell content and edited the manuscript; Barile B contributed the wound healing content; Buccoliero C deepened the discussion on the role of exosomes; Nicchia GP critically revised the manuscript for overall intellectual content; Brunetti G contributed to the transplantation content; and all authors read and approved the final manuscript.
Conflict-of-interest statement: The authors declare having no conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
Corresponding author: Giacomina Brunetti, PhD, Associate Professor of Histology, Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari Aldo Moro, 4 Via Orabona, Bari 70125, Italy. giacomina.brunetti@uniba.it
Received: January 29, 2024
Revised: February 17, 2024
Accepted: April 12, 2024
Published online: June 15, 2024
Processing time: 133 Days and 22.2 Hours
Core Tip

Core Tip: Common management issues are associated with insulin administration for the treatment of diabetes, a heterogeneous metabolic disease characterized by elevated blood glucose levels resulting from the destruction or malfunction of pancreatic β cells. This review focused on alternative therapeutic strategies, such as islet/pancreas implantation and islet/mesenchymal stem cell and induced pluripotent stem cell transplantation. The use of these different approaches is also associated with amelioration of diabetes-related comorbidities.