©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Apr 15, 2024; 15(4): 575-578
Published online Apr 15, 2024. doi: 10.4239/wjd.v15.i4.575
Published online Apr 15, 2024. doi: 10.4239/wjd.v15.i4.575
Nε-carboxymethyl-lysine and inflammatory cytokines, markers and mediators of coronary artery disease progression in diabetes
Sonia Eiras, Translational Cardiology, Health Research Institute, University Hospital of Santiago de Compostela, Santiago de Compostela 15706, Spain
Author contributions: Eiras S contributed to this final scientific letter.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Corresponding author: Sonia Eiras, BSc, Ph.D., Research Scientist, Senior Researcher, Translational Cardiology, Health Research Institute, University Hospital of Santiago de Compostela, Travesía da Choupana s/n, Santiago de Compostela 15706, Spain.
Received: November 5, 2023
Peer-review started: November 5, 2023
First decision: January 6, 2024
Revised: January 8, 2024
Accepted: March 1, 2024
Article in press: March 1, 2024
Published online: April 15, 2024
Processing time: 159 Days and 0 Hours
Peer-review started: November 5, 2023
First decision: January 6, 2024
Revised: January 8, 2024
Accepted: March 1, 2024
Article in press: March 1, 2024
Published online: April 15, 2024
Processing time: 159 Days and 0 Hours
Core Tip
Core Tip: Coronary artery disease (CAD) is associated with 17.8 million deaths annually and nearly 30% have diabetes with insulin resistance. This metabolic disorder increases the circulating glucose levels that allow the non-enzymatic modifications of proteins, lipids, nucleic acids, etc. and form advanced glycation end products (AGEs). Glycosylated hemoglobin is considered a diagnostic marker for diabetes and a risk factor for CAD. However, AGEs through its receptor (RAGE) might increase signal transduction and consequently, inflammatory cytokines, and endothelial dysfunction and be markers and mediators of CAD.