Genotype-based precision nutrition strategies for the prediction and clinical management of type 2 diabetes mellitus

doi:10.4239/wjd.v15.i2.142

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Feb 15, 2024 (publication date) through Feb 20, 2026

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Feb 15, 2024; 15(2): 142-153
Published online Feb 15, 2024. doi: 10.4239/wjd.v15.i2.142

Genotype-based precision nutrition strategies for the prediction and clinical management of type 2 diabetes mellitus

Omar Ramos-Lopez

Omar Ramos-Lopez, Medicine and Psychology School, Autonomous University of Baja California, Tijuana 22390, Baja California, Mexico

Author contributions: Ramos-Lopez O contributed to the writing and revision of this manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Omar Ramos-Lopez, PhD, Professor, Medicine and Psychology School, Autonomous University of Baja California, Universidad 14418, UABC, Parque Internacional Industrial Tijuana, Tijuana 22390, Baja California, Mexico. oscar.omar.ramos.lopez@uabc.edu.mx

Received: October 14, 2023
Peer-review started: October 14, 2023
First decision: December 6, 2023
Revised: December 7, 2023
Accepted: January 11, 2024
Article in press: January 11, 2024
Published online: February 15, 2024
Processing time: 112 Days and 11.1 Hours

Core Tip

Core Tip: The onset and progression of type 2 diabetes mellitus (T2DM) is influenced by complex interrelationships between genetic and dietary factors. Indeed, a number of nutrigenetic studies have identified significant gene-diet interactions related to T2DM predisposition, nutrient metabolic status, and dietary intervention responsiveness. Moreover, this knowledge has motivated the interest for the design and implementation of genotype-based dietary strategies for improving glycemic outcomes compared to conventional nutritional advice. Although more investigation is required, these insights may help to explain disease phenotype heterogeneity, with relevance in precision nutrition for the personalized prevention and clinical management of T2DM.