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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Nov 15, 2024; 15(11): 2237-2241
Published online Nov 15, 2024. doi: 10.4239/wjd.v15.i11.2237
Published online Nov 15, 2024. doi: 10.4239/wjd.v15.i11.2237
Role of intestinal glucagon-like peptide-1 in hypoglycemia response impairment in type 1 diabetes
Chun-Han Cheng, Department of Medical Education, Linkou Chang Gung Memorial Hospital, Taoyuan City 33305, Taiwan
Wen-Rui Hao, Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Ministry of Health and Welfare, Taipei Medical University, New Taipei City 23561, Taiwan
Wen-Rui Hao, Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11002, Taiwan
Tzu-Hurng Cheng, Department of Biochemistry, School of Medicine, College of Medicine, China Medical University, Taichung City 404328, Taiwan
Co-first authors: Chun-Han Cheng and Wen-Rui Hao.
Author contributions: Cheng CH and Hao WR contribute equally to this study as co-first authors. Cheng CH, Hao WR, and Cheng TH have contributed to this study, with Cheng CH and Hao WR primarily responsible for writing, and Cheng TH overseeing revisions; all authors have read and approved the final manuscript.
Conflict-of-interest statement: All authors declare having no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tzu-Hurng Cheng, PhD, Professor, Department of Biochemistry, School of Medicine, College of Medicine, China Medical University, No. 91 Xueshi Road, North District, Taichung City 404328, Taiwan. thcheng@mail.cmu.edu.tw
Received: July 10, 2024
Revised: September 17, 2024
Accepted: October 8, 2024
Published online: November 15, 2024
Processing time: 97 Days and 15.3 Hours
Revised: September 17, 2024
Accepted: October 8, 2024
Published online: November 15, 2024
Processing time: 97 Days and 15.3 Hours
Core Tip
Core Tip: Intestinal glucagon-like peptide-1 is identified as a key factor in modulating counterregulatory responses to hypoglycemia in type 1 diabetes. Gaining a deeper understanding of its role may lead to the development of innovative therapeutic strategies for enhancing hypoglycemia management in patients with diabetes.