Michaelidou M, Pappachan JM, Jeeyavudeen MS. Management of diabesity: Current concepts. World J Diabetes 2023; 14(4): 396-411 [PMID: 37122433 DOI: 10.4239/wjd.v14.i4.396]
Corresponding Author of This Article
Joseph M Pappachan, FRCP, MD, Academic Editor, Consultant in Endocrinology, Professor, Senior Researcher, Department of Endocrinology and Metabolism, Lancashire Teaching Hospitals NHS Trust, Sharoe Green Lane, Preston PR2 9HT, United Kingdom. drpappachan@yahoo.co.in
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Apr 15, 2023; 14(4): 396-411 Published online Apr 15, 2023. doi: 10.4239/wjd.v14.i4.396
Management of diabesity: Current concepts
Maria Michaelidou, Joseph M Pappachan, Mohammad Sadiq Jeeyavudeen
Maria Michaelidou, Joseph M Pappachan, Department of Endocrinology and Metabolism, Lancashire Teaching Hospitals NHS Trust, Preston PR2 9HT, United Kingdom
Joseph M Pappachan, Faculty of Science, Manchester Metropolitan University, Manchester M15 6BH, United Kingdom
Joseph M Pappachan, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PL, United Kingdom
Mohammad Sadiq Jeeyavudeen, Department of Endocrinology & Metabolism, University Hospitals of Edinburgh, Edinburgh EH16 4SA, United Kingdom
Author contributions: Michaelidou M substantially contributed to literature search, interpretation of relevant literature, article drafting, and revision; Pappachan JM conceived the idea, contributed to the interpretation of relevant literature, and revision of the paper; Jeeyavudeen MS contributed to the conception and design of the article, literature search and revision of the article created the figures; and all authors have read and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Joseph M Pappachan, FRCP, MD, Academic Editor, Consultant in Endocrinology, Professor, Senior Researcher, Department of Endocrinology and Metabolism, Lancashire Teaching Hospitals NHS Trust, Sharoe Green Lane, Preston PR2 9HT, United Kingdom. drpappachan@yahoo.co.in
Received: December 25, 2022 Peer-review started: December 25, 2022 First decision: January 9, 2023 Revised: January 15, 2023 Accepted: March 20, 2023 Article in press: March 20, 2023 Published online: April 15, 2023 Processing time: 108 Days and 0.5 Hours
Core Tip
Core Tip: The worldwide prevalence of diabesity is increasing exponentially because of the global obesity pandemic in the past few decades. This is also expected to increase the prevalence of other associated chronic disorders such as hypertension, dyslipidemia, metabolic-associated fatty liver disease (MAFLD), obstructive sleep apnoea (OSA), and cardiovascular disease. Rational management of diabesity involves prompt control of diabetes while also optimally addressing other comorbidities such as obesity, hypertension, dyslipidemia, MAFLD, OSA and cardiovascular risk. Appropriate selection of the antidiabetic therapeutic agents and early planning of metabolic surgery when indicated are crucial to scientifically approach patients with diabesity. This evidence-based review addresses the key issues regarding management of diabesity.
