Diabetes mellitus and prostate cancer risk: A mendelian randomization analysis

doi:10.4239/wjd.v14.i12.1839

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Diabetes. Dec 15, 2023; 14(12): 1839-1848
Published online Dec 15, 2023. doi: 10.4239/wjd.v14.i12.1839

Diabetes mellitus and prostate cancer risk: A mendelian randomization analysis

Jian-Xu Yuan, Qing Jiang, Sheng-Jie Yu

Jian-Xu Yuan, Qing Jiang, Sheng-Jie Yu, Department of Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China

Author contributions: Jiang Q designed the research plan; Yuan JX wrote the first draft; Yuan JX and Yu SJ participated in data collection and analysis; Yu SJ made revisions to the manuscript; all authors contributed to the article and approved the submitted version.

Conflict-of-interest statement: All authors declare that this study was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest.

Data sharing statement: Publicly available datasets were analyzed in this study. The data are as follows: IEU OpenGWAS project:https://gwas.mrcieu.ac.uk/datasets/ukb-a-57/; https://gwas.mrcieu.ac.uk/datasets/ukb-a-306/.

Corresponding author: Sheng-Jie Yu, MD, PhD, Associate Chief Physician, Associate Professor, Surgeon, Teacher, Department of Surgery, The Second Affiliated Hospital of Chongqing Medical University, No. 74-76 Linjiang Road, Chongqing 400010, China. bbyddh@sina.com

Received: September 2, 2023
Peer-review started: September 2, 2023
First decision: November 14, 2023
Revised: November 20, 2023
Accepted: December 1, 2023
Article in press: December 1, 2023
Published online: December 15, 2023
Processing time: 102 Days and 21 Hours

Core Tip

Core Tip: Diabetes mellitus (DM) is a chronic metabolic disease caused by many factors. Prostate cancer (PCa) is a common malignant tumor in men and is the second leading cause of cancer death. The Mendelian randomization (MR) method uses genetic variation as an instrumental variable to detect and quantify causal relationships, which can avoid the impact of confounding factors on the accuracy of the research results. This makes it more reliable than observational study or even randomized controlled trial. This study aimed to clarify the relationship between DM and PCa using MR analysis. Through MR analysis of a large sample with three different methods, this study found that DM was an independent risk factor for PCa, providing new directions for the prevention and treatment of PCa.