Diabetes mellitus and prostate cancer risk: A mendelian randomization analysis

doi:10.4239/wjd.v14.i12.1839

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Dec 15, 2023 (publication date) through Feb 26, 2026

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Dec 15, 2023; 14(12): 1839-1848
Published online Dec 15, 2023. doi: 10.4239/wjd.v14.i12.1839

Diabetes mellitus and prostate cancer risk: A mendelian randomization analysis

Jian-Xu Yuan, Qing Jiang, Sheng-Jie Yu

Jian-Xu Yuan, Qing Jiang, Sheng-Jie Yu, Department of Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China

Author contributions: Jiang Q designed the research plan; Yuan JX wrote the first draft; Yuan JX and Yu SJ participated in data collection and analysis; Yu SJ made revisions to the manuscript; all authors contributed to the article and approved the submitted version.

Conflict-of-interest statement: All authors declare that this study was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest.

Data sharing statement: Publicly available datasets were analyzed in this study. The data are as follows: IEU OpenGWAS project:https://gwas.mrcieu.ac.uk/datasets/ukb-a-57/; https://gwas.mrcieu.ac.uk/datasets/ukb-a-306/.

Corresponding author: Sheng-Jie Yu, MD, PhD, Associate Chief Physician, Associate Professor, Surgeon, Teacher, Department of Surgery, The Second Affiliated Hospital of Chongqing Medical University, No. 74-76 Linjiang Road, Chongqing 400010, China. bbyddh@sina.com

Received: September 2, 2023
Peer-review started: September 2, 2023
First decision: November 14, 2023
Revised: November 20, 2023
Accepted: December 1, 2023
Article in press: December 1, 2023
Published online: December 15, 2023
Processing time: 102 Days and 21 Hours

ARTICLE HIGHLIGHTS

Research background

Some studies have shown a relationship between diabetes mellitus (DM) and prostate cancer (PCa); however, this specific relationship remains inconclusive.

Research motivation

Mendelian randomization (MR) has been a widely used analytical method in recent years for inferring epidemiological causes. We believe that MR can explain the causal relationship between DM and PCa.

Research objectives

Find the causal relationship between DM and PCa.

Research methods

We downloaded the relevant data from a public database, used three different MR methods, and conducted a sensitivity analysis for validation.

Research results

These results indicated that DM was an independent risk factor for PCa. The odds ratio (OR) values obtained using the inverse variance weighted method in this study were as follows: OR = 1.018 (95% confidence interval: 1.004-1.032), P = 0.014.

Research conclusions

Through MR analysis of a large sample, this study found that DM was an independent risk factor for PCa, providing new directions for the prevention and treatment of PCa.

Research perspectives

This study investigated the potential relationship between DM and PCa using MR.